BAI1 Antibody
(Synonyms: BAI1, ADGRB1, Adhesion G protein-coupled receptor B1, Brain-specific angiogenesis inhibitor 1)BAI1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to BAI1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, ICC/IF
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Reactivity :
Human, Mouse
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-500 |
Product Details
BAI1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to BAI1.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse
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Observed Molecular WeightObserved band size: 174 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 173 kDa
Synthetic peptide corresponding to the center region of human BAI1.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
BAI1 is a Phosphatidylserine receptor which enhances the engulfment of apoptotic cells. Also mediates the binding and engulfment of Gram-negative bacteria. Stimulates production of reactive oxygen species by macrophages in response to Gram-negative bacteria, resulting in enhanced microbicidal macrophage activity. In the gastric mucosa, required for recognition and engulfment of apoptotic gastric epithelial cells. Promotes myoblast fusion (By similarity). Activates the Rho pathway in a G protein-dependent manner. Inhibits MDM2-mediated ubiquitination and degradation of DLG4/PSD95, promoting DLG4 stability and regulating synaptic plasticity (By similarity). Required for the formation of dendritic spines by ensuring the correct localization of PARD3 and TIAM1 (By similarity). Potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53/TP53 signal in suppression of glioblastoma[1][2][3][4].
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Subcellular Localization
Cell membrane; Cell projection, phagocytic cup; Cell junction, focal adhesion; Cell projection, dendritic spine; Postsynaptic density
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Expression
Tissue_Specificity: Expressed in brain (at protein level). Expressed on mononuclear phagocytes and monocyte-derived macrophages in the gastric mucosa (at protein level). Expressed in normal pancreatic tissue but not in pancreatic tumor tissue. Reduced or no expression is observed in some glioblastomas.
Induction: By p53/TP53. -
Isoforms & Post-Translational Modification
BAI1 has an amino acid length of 1584, molecular weight is 173501 Da.
Proteolytically cleaved to produce vasculostatin-40 and vasculostatin-120. Vasculostatin-40 is the major form and is produced through proteolytic cleavage by MMP14 between residues 321 and 329 with cleavage likely to be between Ser-326 and Leu-327. -
Subunit
Interacts with ELMO1 and DOCK (By similarity).
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SwissProt ID
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Synonyms
BAI1, ADGRB1, Adhesion G protein-coupled receptor B1, Brain-specific angiogenesis inhibitor 1
Documentation
[1]. Das S, et al. Brain angiogenesis inhibitor 1 is expressed by gastric phagocytes during infection with Helicobacter pylori and mediates the recognition and engulfment of human apoptotic gastric epithelial cells. FASEB J. 2014 May;28(5):2214-24. [Content Brief]
[2]. Billings EA, et al. The adhesion GPCR BAI1 mediates macrophage ROS production and microbicidal activity against Gram-negative bacteria. Sci Signal. 2016 Feb 2;9(413):ra14. [Content Brief]
[3]. Stephenson JR, et al. Brain-specific angiogenesis inhibitor-1 signaling, regulation, and enrichment in the postsynaptic density. J Biol Chem. 2013 Aug 2;288(31):22248-56. [Content Brief]
[4]. Duda DG, et al. Overexpression of the p53-inducible brain-specific angiogenesis inhibitor 1 suppresses efficiently tumour angiogenesis. Br J Cancer. 2002 Feb 1;86(3):490-6. [Content Brief]
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