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Art. -Nr.: HY-115930

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Bim-IN-1

Kundenbewertung

Based on 1 Customer Validation

Bim-IN-1 is a potent Bim expression inhibitor. Bim-IN-1 reduces Bim expression levels and has little inhibitory effect upon protein kinase A activity and minimal toxicity.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 99.57%
CAS. Nr.: 2909483-36-7
Formel: C₁₉H₂₀Cl₂FNO₂S
Molecular Weight:416.34

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Bim-IN-1 Chemical Structure

CAS. Nr.: 2909483-36-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Bim-IN-1 is a potent Bim expression inhibitor. Bim-IN-1 reduces Bim expression levels and has little inhibitory effect upon protein kinase A activity and minimal toxicity^[1].

IC₅₀ & Target

Bim

Alle Bcl-2 Family Isoform-spezifische Produkte anzeigen :

In Vitro

Bim-IN-1 (compound 63, mouse embryonic fibroblasts; 0, 25, 50 μM; 72 hours) demonstrates strong reduction of Bim expression levels at a low micromolar level with low toxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2909483-36-7
Appearance Solid
Molecular Weight 416.34
Formel C₁₉H₂₀Cl₂FNO₂S
Color White to light yellow
SMILES

FC1=CC(C2N(S(=O)(CC3=CC=C(Cl)C=C3Cl)=O)CCCCC2)=CC=C1
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 200 mg/mL (480.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.4019 mL

12.0094 mL

24.0188 mL

5 mM

0.4804 mL

2.4019 mL

4.8038 mL

10 mM

0.2402 mL

1.2009 mL

2.4019 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Richards BJ, et al. Discovery, synthesis and exploration of N-benzylsulfonyl-2-phenylazepanes as inhibitors of Bim expression in a mouse embryonic fibroblast model. Bioorg Chem. 2022; 120:105635. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.4019 mL	12.0094 mL	24.0188 mL	60.0471 mL
	5 mM	0.4804 mL	2.4019 mL	4.8038 mL	12.0094 mL
	10 mM	0.2402 mL	1.2009 mL	2.4019 mL	6.0047 mL
	15 mM	0.1601 mL	0.8006 mL	1.6013 mL	4.0031 mL
	20 mM	0.1201 mL	0.6005 mL	1.2009 mL	3.0024 mL
	25 mM	0.0961 mL	0.4804 mL	0.9608 mL	2.4019 mL
	30 mM	0.0801 mL	0.4003 mL	0.8006 mL	2.0016 mL
	40 mM	0.0600 mL	0.3002 mL	0.6005 mL	1.5012 mL
	50 mM	0.0480 mL	0.2402 mL	0.4804 mL	1.2009 mL
	60 mM	0.0400 mL	0.2002 mL	0.4003 mL	1.0008 mL
	80 mM	0.0300 mL	0.1501 mL	0.3002 mL	0.7506 mL
	100 mM	0.0240 mL	0.1201 mL	0.2402 mL	0.6005 mL

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

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Bim-IN-1

Anti-Cardiovascular Disease Compound Library

Anti-Blood Cancer Compound Library

Mitochondria-Targeted Compound Library

Anti-Hematopathy Compound Library

Anti-Ovarian Cancer Compound Library

Mitophagy Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Apoptosis Compound Library

Alle Bcl-2 Family Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Bim-IN-1

Anti-Cardiovascular Disease Compound Library

Anti-Blood Cancer Compound Library

Mitochondria-Targeted Compound Library

Anti-Hematopathy Compound Library

Anti-Ovarian Cancer Compound Library

Mitophagy Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Apoptosis Compound Library

Alle Bcl-2 Family Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Bim-IN-1 Related Classifications

HY-115930 Related Classifications