country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-13412

Copy Link Print Information

Cariporide (mesilate)

Name: Cariporide (mesilate)
Brand: MedChemExpress
SKU: HY-13412
Availability: PreOrder

(Synonyms: HOE-642)

12 Cited Publications

Kundenbewertung

Based on 12 publication(s) in Google Scholar

Cariporide is a Na+/H+ Exchanger 1 (NHE-1) inhibitor. Cariporide inhibits the expression of monocyte endothelial cell adhesion and intercellular adhesion molecule-1 (ICAM-1) mediated by high glucose (HG) by inhibiting the activation of NHE-1.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 159138-81-5
Formel: C₁₃H₂₁N₃O₆S₂
Molecular Weight:379.45

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Cariporide (mesilate) Chemical Structure

CAS. Nr.: 159138-81-5

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität

Beschreibung

Alle Sodium Channel Isoform-spezifische Produkte anzeigen :

Chemical Information

CAS. Nr. 159138-81-5
Molecular Weight 379.45
Formel C₁₃H₂₁N₃O₆S₂
SMILES

O=C(NC(N)=N)C1=CC=C(C(C)C)C(S(=O)(C)=O)=C1.CS(=O)(O)=O
Synonyms

HOE-642
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (12)

All Cell Imaging/StainingOthersIF

Sort by:

Journal Impact Factor

Acta Pharm Sin B

Structural repurposing of SGLT2 inhibitor empagliflozin for strengthening anti-heart failure activity with lower glycosuria. [Abstract]

2023 Apr;13(4):1671-1685. PMID: 37139418
ACS Environ Au

Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]

2025 Aug 5;5(6):573-582. PMID: 41277996
Anal Chem

Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]

2025 Jun 3;97(21):11099-11109. PMID: 40401576
Hum Reprod

Flagellar pH homeostasis mediated by Na+/H+ exchangers regulates human sperm functions through coupling with CatSper and KSper activation. [Abstract]

2024 Apr 3;39(4):674-688. PMID: 38366201
JCI Insight

Acid-base homeostasis orchestrated by NHE1 defines pancreatic stellate cell phenotype in pancreatic cancer. [Abstract]

2023 Oct 9;8(19):e170928. PMID: 37643024

Cariporide (mesilate) purchased from MedChemExpress. Usage Cited in: JCI Insight. 2023 Oct 9;8(19):e170928. [Abstract]

Immunocytochemistry of PDAC-like PSCs in the absence (left) or presence (right) of cariporide (CARI: 10 μM).

Cariporide (mesilate) purchased from MedChemExpress. Usage Cited in: JCI Insight. 2023 Oct 9;8(19):e170928. [Abstract]

Immunocytochemistry of CAFs derived from KPfC mice after a 1-month treatment with vehicle or gemcitabine + Cariporide (3 mg/kg i.p.).
Drug Des Devel Ther

GBVAM as a Novel NHE1 Inhibitor Alleviates Doxorubicin-Induced Cardiotoxicity via PI3K/Akt/mTOR Pathway. [Abstract]

2026 May 12:20:585989. PMID: 42148365
Am J Pathol

Lipopolysaccharide Triggers Luminal Acidification to Promote Defense Against Bacterial Infection in Vaginal Epithelium. [Abstract]

2024 Dec;194(12):2290-2301. PMID: 39222908

Cariporide (mesilate) purchased from MedChemExpress. Usage Cited in: Am J Pathol. 2024 Dec;194(12):2290-2301. [Abstract]

Statistical analysis showing the effect of Cariporide (10 μmol/L) on the enhanced pHi recovery induced by LPS (10 μg/mL) stimulation for 6 hours in VK2/E6E7 cells.
iScience

2026 Feb 19;29(3).
FASEB J

AMP-activated protein kinase regulates glycocalyx impairment and macrophage recruitment in response to low shear stress. [Abstract]

2019 Jun;33(6):7202-7212. PMID: 30860864
Am J Physiol Heart Circ Physiol

Empagliflozin treatment rescues abnormally reduced Na currents in ventricular cardiomyocytes from dystrophin-deficient mdx mice. [Abstract]

2024 Feb 1;326(2):H418-H425. PMID: 38099845

Cariporide (mesilate) purchased from MedChemExpress. Usage Cited in: Am J Physiol Heart Circ Physiol. 2024 Feb 1;326(2):H418-H425. [Abstract]

original current traces of a control mdx (mdx DMSO), a cariporide-treated mdx (mdx CARI, 24-h incubation at 10 µM concentration), and a cariporide-plus EMPA-treated (mdx CARI + EMPA) cardiomyocyte.
Biomed Pharmacother

Sodium glucose co-transporter 2 inhibitor empagliflozin prevents endothelial dysfunction induced by oscillatory shear stress. [Abstract]

2025 Nov:192:118670. PMID: 41130096

Cariporide (mesilate) purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2025 Nov:192:118670. [Abstract]

To test the involvement of NHE1 and NCX in the ROS inhibition effect of EMPA, HCAECs were pre-incubated with either Vehicle, Cariporide (10 µM) or ORM-10962 (100 nM), in combination with EMPA or not, for 2 h before exposure to OSS. After 6 h, ROS was measured using live cell image and quantified with MFI.
Res Sq

2024 Jun 11.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Wang SX, et al. Cariporide inhibits high glucose-mediated adhesion of monocyte-endothelial cell and expression of intercellular adhesion molecule-1. Life Sci. 2006 Aug 29;79(14):1399-404. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

Cariporide (mesilate)

12 Cited Publications

100 mg Angebot einholen

Subscribe to the

MedChemExpress

Newsletter

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen

Amount: USD 0.00

Biologische Aktivität
- Beschreibung
Chemical Information
Publications (12)
Reinheit & Dokumentation
Verweise

1/16
1/16

Cariporide (mesilate) purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2025 Nov:192:118670. [Abstract]

Customer Validation
To test the involvement of NHE1 and NCX in the ROS inhibition effect of EMPA, HCAECs were pre-incubated with either Vehicle, Cariporide (10 µM) or ORM-10962 (100 nM), in combination with EMPA or not, for 2 h before exposure to OSS. After 6 h, ROS was measured using live cell image and quantified with MFI.
1/16

Cariporide (mesilate) purchased from MedChemExpress. Usage Cited in: Am J Pathol. 2024 Dec;194(12):2290-2301. [Abstract]

Customer Validation
Statistical analysis showing the effect of Cariporide (10 μmol/L) on the enhanced pHi recovery induced by LPS (10 μg/mL) stimulation for 6 hours in VK2/E6E7 cells.
1/16

Cariporide (mesilate) purchased from MedChemExpress. Usage Cited in: Am J Physiol Heart Circ Physiol. 2024 Feb 1;326(2):H418-H425. [Abstract]

Customer Validation
original current traces of a control mdx (mdx DMSO), a cariporide-treated mdx (mdx CARI, 24-h incubation at 10 µM concentration), and a cariporide-plus EMPA-treated (mdx CARI + EMPA) cardiomyocyte.
1/16

Cariporide (mesilate) purchased from MedChemExpress. Usage Cited in: JCI Insight. 2023 Oct 9;8(19):e170928. [Abstract]

Customer Validation
Immunocytochemistry of PDAC-like PSCs in the absence (left) or presence (right) of cariporide (CARI: 10 μM).
1/16

Cariporide (mesilate) purchased from MedChemExpress. Usage Cited in: JCI Insight. 2023 Oct 9;8(19):e170928. [Abstract]

Customer Validation
Immunocytochemistry of CAFs derived from KPfC mice after a 1-month treatment with vehicle or gemcitabine + Cariporide (3 mg/kg i.p.).

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

Cariporide (mesilate)

Publications Citing Use of MedChemExpress (MCE) Cariporide (mesilate)

Alle Sodium Channel Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (12)

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Cariporide (mesilate) Related Classifications

HY-13412 Related Classifications

Bioz