DCAF1 binder 1
Based on 1 Customer Validation
DCAF1 binder 1 is a selective for the CRL4 DCAF1 E3 ligase complex. DCAF1 binder 1 is a ligands for E3 Ligase, involving in targeted protein degradation (TPD).
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- Reinheit: 98.77%
- CAS. Nr.: 3053860-67-3
- Formel: C28H35ClN6O
- Molecular Weight:507.07
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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Cereblon |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 3053860-67-3
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Appearance Solid
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Molecular Weight 507.07
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Formel C28H35ClN6O
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Color White to off-white
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SMILES
NCCNC1=NC(C2(C3=CC=C(C=C3)Cl)CCCCC2)=NC4=C1C=CC(N5CCN(CC5)C(C)=O)=C4
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 50 mg/mL (98.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.9721 mL | 9.8606 mL | 19.7211 mL | 49.3029 mL |
| 5 mM | 0.3944 mL | 1.9721 mL | 3.9442 mL | 9.8606 mL | |
| 10 mM | 0.1972 mL | 0.9861 mL | 1.9721 mL | 4.9303 mL | |
| 15 mM | 0.1315 mL | 0.6574 mL | 1.3147 mL | 3.2869 mL | |
| 20 mM | 0.0986 mL | 0.4930 mL | 0.9861 mL | 2.4651 mL | |
| 25 mM | 0.0789 mL | 0.3944 mL | 0.7888 mL | 1.9721 mL | |
| 30 mM | 0.0657 mL | 0.3287 mL | 0.6574 mL | 1.6434 mL | |
| 40 mM | 0.0493 mL | 0.2465 mL | 0.4930 mL | 1.2326 mL | |
| 50 mM | 0.0394 mL | 0.1972 mL | 0.3944 mL | 0.9861 mL | |
| 60 mM | 0.0329 mL | 0.1643 mL | 0.3287 mL | 0.8217 mL | |
| 80 mM | 0.0247 mL | 0.1233 mL | 0.2465 mL | 0.6163 mL |
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