TREM2 - triggering receptor expressed on myeloid cells 2 Gene

Also Known as PLOSL2; TREM-2; Trem2a; Trem2b; Trem2c

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 54209

About TREM2

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:41,158,508-41,163,116 (from NCBI)

This gene has 3 transcripts (splice variants), 111 orthologues, 13 paralogues and is associated with 8 phenotypes. Broad expression in brain (RPKM 11.5), lung (RPKM 7.7) and 14 other tissues.

Summary

This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]

TREM2 Products (2)

mRNA	Protein	Name
NM_001271821.2	NP_001258750.1	triggering receptor expressed on myeloid cells 2 precursor isoform 2 precursor
NM_018965.4	NP_061838.1	triggering receptor expressed on myeloid cells 2 precursor isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables amyloid-beta binding	IPI IPI: Inferred from physical interaction	29518356	GOA
enables apolipoprotein A-I binding	IPI IPI: Inferred from physical interaction	27477018	GOA
enables apolipoprotein binding	IPI IPI: Inferred from physical interaction	27477018	GOA
enables beta-catenin binding	IPI IPI: Inferred from physical interaction	30683932	GOA
enables high-density lipoprotein particle binding	IDA IDA: Inferred from direct assay	27477018	GOA
enables kinase activator activity	IMP IMP: Inferred from mutant phenotype	31902528	GOA
enables lipoprotein particle binding	IDA IDA: Inferred from direct assay	27477018	GOA
enables low-density lipoprotein particle binding	IDA IDA: Inferred from direct assay	27477018	GOA
enables phosphatidylethanolamine binding	IDA IDA: Inferred from direct assay	31101881	GOA
enables phosphatidylserine binding	IDA IDA: Inferred from direct assay	31101881	GOA
enables phospholipid binding	IDA IDA: Inferred from direct assay	27995897	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11602640	GOA
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	29518356	GOA
enables scaffold protein binding	IPI IPI: Inferred from physical interaction	11602640	GOA
enables signaling receptor activity	IMP IMP: Inferred from mutant phenotype	32514138	GOA
enables sulfatide binding	IDA IDA: Inferred from direct assay	31902528	GOA
enables transmembrane signaling receptor activity	IDA IDA: Inferred from direct assay	29518356	GOA
enables very-low-density lipoprotein particle binding	IDA IDA: Inferred from direct assay	27477018	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
acts upstream of or within positive effect CXCL12-activated CXCR4 signaling pathway	IMP IMP: Inferred from mutant phenotype	33097708	GOA
involved in amyloid-beta clearance	IDA IDA: Inferred from direct assay	27477018	GOA
involved in amyloid-beta clearance by cellular catabolic process	IMP IMP: Inferred from mutant phenotype	33097708	GOA
involved in cellular response to amyloid-beta	IDA IDA: Inferred from direct assay	29518356	GOA
involved in cellular response to lipid	IMP IMP: Inferred from mutant phenotype	32514138	GOA
involved in cellular response to lipoprotein particle stimulus	IDA IDA: Inferred from direct assay	27477018	GOA
involved in cellular response to oxidised low-density lipoprotein particle stimulus	IDA IDA: Inferred from direct assay	31902528	GOA
involved in dendritic cell differentiation	IDA IDA: Inferred from direct assay	11602640	GOA
acts upstream of positive effect memory	IDA IDA: Inferred from direct assay	31462511	GOA
acts upstream of positive effect memory	IMP IMP: Inferred from mutant phenotype	29518357	GOA
acts upstream of or within negative regulation of NLRP3 inflammasome complex assembly	IMP IMP: Inferred from mutant phenotype	32514138	GOA
involved in negative regulation of macrophage colony-stimulating factor signaling pathway	IMP IMP: Inferred from mutant phenotype	33097708	GOA
involved in negative regulation of neuroinflammatory response	IMP IMP: Inferred from mutant phenotype	32514138	GOA
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	30683932	GOA
acts upstream of or within osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	21841309	GOA
involved in osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	12925681	GOA
involved in phagocytosis, recognition	IMP IMP: Inferred from mutant phenotype	32514138	GOA
involved in positive regulation of C-C chemokine receptor CCR7 signaling pathway	IDA IDA: Inferred from direct assay	11602640	GOA
involved in positive regulation of CD40 signaling pathway	IDA IDA: Inferred from direct assay	11602640	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	11602640	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	27995897	GOA
involved in positive regulation of amyloid-beta clearance	IMP IMP: Inferred from mutant phenotype	31235932	GOA
involved in positive regulation of antigen processing and presentation of peptide antigen via MHC class II	IDA IDA: Inferred from direct assay	11602640	GOA
involved in positive regulation of calcium-mediated signaling	IDA IDA: Inferred from direct assay	11602640	GOA
involved in positive regulation of engulfment of apoptotic cell	IMP IMP: Inferred from mutant phenotype	24990881	GOA
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	32514138	GOA
involved in positive regulation of kinase activity	IDA IDA: Inferred from direct assay	31902528	GOA
involved in positive regulation of microglial cell activation	IMP IMP: Inferred from mutant phenotype	24990881	GOA
involved in positive regulation of microglial cell migration	IMP IMP: Inferred from mutant phenotype	33097708	GOA
acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	32514138	GOA
involved in positive regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	11602640	GOA
involved in positive regulation of phagocytosis	IMP IMP: Inferred from mutant phenotype	29518357	GOA
acts upstream of positive regulation of phagocytosis, engulfment	IMP IMP: Inferred from mutant phenotype	32514138	GOA
involved in positive regulation of phagocytosis, engulfment	IMP IMP: Inferred from mutant phenotype	28855300	GOA
involved in positive regulation of protein localization to plasma membrane	IDA IDA: Inferred from direct assay	11602640	GOA
involved in positive regulation of protein secretion	IMP IMP: Inferred from mutant phenotype	27044754	GOA
involved in positive regulation of synapse pruning	IMP IMP: Inferred from mutant phenotype	33097708	GOA
acts upstream of regulation of lipid metabolic process	IMP IMP: Inferred from mutant phenotype	32514138	GOA
involved in regulation of plasma membrane bounded cell projection organization	IGI IGI: Inferred from genetic interaction	29518356	GOA
involved in response to axon injury	IMP IMP: Inferred from mutant phenotype	31235932	GOA
acts upstream of positive effect social behavior	IMP IMP: Inferred from mutant phenotype	29752066	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in membrane	IDA IDA: Inferred from direct assay	11602640	GOA
is active in plasma membrane	IDA IDA: Inferred from direct assay	24078628	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	27995897	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	24990881	GOA
located in plasma membrane raft	IDA IDA: Inferred from direct assay	31413141	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TREM2 Protein Structure

V-set

0
100
200
230 a.a.

Protein Preferred Names	Protein Names
triggering receptor expressed on myeloid cells 2	triggering receptor expressed on monocytes 2

TREM2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	TREM2	Q9NZC2	APOE	Homo sapiens	P02649	BLI	30341064
Intra	TREM2	Q9NZC2	TYROBP	Homo sapiens	O43914	Renilla Luciferase	28490631
Intra	TREM2	Q9NZC2	TYROBP	Homo sapiens	O43914	Crosslink	28490631
Intra	TREM2	Q9NZC2	TYROBP	Homo sapiens	O43914	IF	28490631
Intra	TREM2	Q9NZC2	TYROBP	Homo sapiens	O43914	Anti Bait CoIP	11602640
Intra	TREM2	Q9NZC2	PSEN1	Homo sapiens	P49768	Anti Tag CoIP	29611543
Intra	TREM2	Q9NZC2	PSEN1	Homo sapiens	P49768	Confocal	29611543
Intra	TREM2	Q9NZC2	PSEN1	Homo sapiens	P49768	Pull Down	29611543
Intra	TREM2	Q9NZC2	P05067-PRO_0000000092	Homo sapiens	P05067-PRO_0000000092	ELISA	30341064
Intra	TREM2	Q9NZC2	P05067-PRO_0000000092	Homo sapiens	P05067-PRO_0000000092	BLI	30341064

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TREM2 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P70534	TREM-2 Protein, Human (HEK293, His)	Q9NZC2-1 (H19-S174)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78222	TREM-2 Protein, Human (Biotinylated, HEK293, His-Avi)	Q9NZC2-1 (H19-S174)	≥ 95%, as determined by Bis-Tris PAGE.

TREM2 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P80920	TREM2 Antibody	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 2	PLOSL2
Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1	Nasu-Hakola Disease Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy Plosl Nhd Presenile Dementia With Bone Cysts Plo-Sl PLOSL1 Dementia, Prefrontal, With Bone Cysts Dementia, Progressive, With Lipomembranous Polycystic Osteodysplasia Brain-Bone-Fat Disease Progressive Dementia With Lipomembranous Polycystic Osteodysplasia Brain-Bone-Fat Disease
Frontotemporal Dementia	Pallidopontonigral Degeneration Frontotemporal Lobar Degeneration Semantic Dementia FTD Frontotemporal Lobe Dementia Multiple System Tauopathy With Presenile Dementia Dementia, Frontotemporal Frontotemporal Dementia With Parkinsonism Mstd Frontotemporal Lobar Degeneration With Tau Inclusions Ftld With Tau Inclusions Dementia, Frontotemporal, With Parkinsonism Fldem Ftdp17 Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex Ddpac Wilhelmsen-Lynch Disease Wld Ppnd Dementia, Frontotemporal, With Or Without Parkinsonism Semantic Primary Progressive Aphasia Semantic Variant Ppa Wilhemsen-Lynch Disease Frontotemporal Dementia-Amyotrophic Lateral Sclerosis Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17 Ftd-Als Ftld Pick Complex Pick Disease Of The Brain Frontotemporal Dementia With Parkinsonism-17 Grn-Related Frontotemporal Dementia Frontotemporal Dementia With Motor Neuron Disease Dementia In Fronto-Temporal Lobar Degeneration Ftd - [Frontotemporal Dementia] Temple Dementia Frontal Lobe Dementia
Solitary Bone Cyst	Unicameral Bone Cyst Bone Cysts Cyst Of Bone Local Cyst Of Bone Simple Bone Cyst Solitary Bone Cyst, Unspecified Site Traumatic Bone Cyst
Pick Disease Of Brain	Pick Disease Pick'S Disease Pick Disease Of The Brain Lobar Atrophy Of Brain Dementia With Lobar Atrophy And Neuronal Cytoplasmic Inclusions Behavioral Variant Of Frontotemporal Dementia Dementia In Pick'S Disease Lobar Atrophy Of The Brain Bvftd Bv-Ftd PIDB Picks Disease
Early-Onset, Autosomal Dominant Alzheimer Disease	Familial Alzheimer Disease Early-Onset Autosomal Dominant Alzheimer Disease Eofad Early-Onset Familial Autosomal Dominant Alzheimer Disease Alzheimer'S Disease, Familial
Progressive Non-Fluent Aphasia	Non-Fluent Variant Ppa Progressive Nonfluent Aphasia Non-Fluent Primary Progressive Aphasia Agramatic Variant Of Ppa Agramatic Variant Of Primary Progressive Aphasia Primary Progressive Non Fluent Aphasia Primary Progressive Nonfluent Aphasia
Basal Ganglia Calcification	Fahr'S Syndrome Fahr'S Disease Fahr Disease
Dementia	Dementias Presenile Dementia Alzheimer Type Dementia Alzheimer Sclerosis Alzheimer Disease Dementia Alzheimer Dementia Primary Degenerative Alzheimer Type Dementia End Stage Alzheimer'S Dementia Alzheimer'S Type Atypical Dementia Alzheimer Type Presenile Dementia Early Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 2 Dementia In Alzheimer Disease With Early Onset Early Onset Alzheimer Type Dementia, Uncomplicated Primary Degenerative Alzheimer Type Dementia, Early Onset Primary Degenerative Alzheimer Type Dementia, Presenile Onset, Uncomplicated Alzheimer Disease Dementia With Early Onset Presenile Sclerosis Presenile Brain Sclerosis Presenile Alzheimer Brain Sclerosis Late Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 1 Dementia In Alzheimer Disease With Late Onset Primary Degenerative Alzheimer Type Dementia, Late Onset Sdat - [Senile Dementia, Alzheimer Type] Alzheimer Disease Dementia With Late Onset Late Onset Alzheimer Brain Sclerosis Senile Alzheimer Brain Disease Senile Alzheimer Brain Sclerosis Senile Primary Degenerative Alzheimer Type Dementia Senile Dementia Of The Alzheimer Type Arteriosclerotic Dementia Strategic-Infarct Dementia Post Stroke Dementia Vascular Cognitive Impairment Vascular Dementia Dementia Of The Lewy Body Type Dementia With Lewy Bodies Sdlt - [Senile Dementia Of The Lewy Body Type] Senile Dementia Of The Lewy Body Type Alcohol-Related Dementia Alcoholic Dementia Nos Alcohol-Induced Dementia Alcoholic Brain Syndrome Chronic Alcoholic Brain Syndrome Alcohol Dementia Late Onset Alcoholic Psychosis Residual And Late-Onset Alcohol-Induced Psychotic Disorder Mental And Behavioural Disorders Due To Use Of Sedatives Or Hypnotics, Residual And Late-Onset Psychotic Disorder Late-Onset Psychoactive Substance-Induced Psychotic Disorder Inhalant Dementia Volatile Solvents Dementia Dementia In Paralysis Agitans Pdd - [Parkinson Disease Dementia] Dementia Syndrome Of Parkinson Disease Dementia In Parkinson Disease Parkinson Related Dementia Dementia In Huntington Chorea Hiv - [Human Immunodeficiency Virus] Dementia Hiv- [Human Immunodeficiency Virus] Associated Cognitive Motor Complex Hiv- [Human Immunodeficiency Virus] Associated Dementia Complex Aids - [Acquired Immunodeficiency Syndrome] Dementia Complex Aids Related Dementia Dementia Due To Niacin Deficiency
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Maxillary Sinusitis
Parkinson Disease 23, Autosomal Recessive Early-Onset	Autosomal Recessive Early-Onset Parkinson Disease 23 PARK23 Parkinson Disease 23, Autosomal Recessive, Early Onset Parkinson'S Disease 23 Autosomal Recessive Early-Onset Parkinson'S Disease 23 Parkinson Disease, Type 23, Autosomal Recessive, Early Onset
Leukoencephalopathy, Hereditary Diffuse, With Spheroids 1	Hereditary Diffuse Leukoencephalopathy With Spheroids Adult-Onset Leukoencephalopathy With Axonal Spheroids And Pigmented Glia Alsp Gpsc Subcortical Gliosis Of Neumann Leukoencephalopathy, Diffuse Hereditary, With Spheroids 1 Autosomal Dominant Leukoencephalopathy With Neuroaxonal Spheroids Hdls HDLS1 Leukoencephalopathy, Adult-Onset, With Axonal Spheroids And Pigmented Glia Gliosis, Familial Progressive Subcortical Leukoencephalopathy, Diffuse Hereditary, With Spheroids Pold Pigmentary Orthochromatic Leukodystrophy Hereditary Diffuse Leukoencephalopathy With Axonal Spheroids And Pigmented Glia Familial Progressive Subcortical Gliosis Leukoencephalopathy With Neuroaxonal Spheroids, Autosomal Dominant Dementia, Familial, Neumann Type Adult-Onset Leukodystrophy With Neuroaxonal Spheroids Hereditary Diffuse Leukoencephalopathy With Axonal Spheroids Neuroaxonal Leukodystrophy Fpsg Familial Dementia, Neumann Type Familial Dementia Neumann Type Leukoencephalopathy, Diffuse Hereditary, With Spheroid
Amyotrophic Lateral Sclerosis 3	ALS3 Amyotrophic Lateral Sclerosis Type 3
Cerebral Amyloid Angiopathy, Cst3-Related	Cerebral Amyloid Angiopathy Hereditary Cerebral Hemorrhage With Amyloidosis Hchwa Hereditary Cystatin C Amyloid Angiopathy Cerebral Amyloid Angiopathy, Familial Amyloidosis, Cerebroarterial, Icelandic Type Amyloidosis Vi Cerebral Hemorrhage, Hereditary, With Amyloidosis Cst3-Related Cerebral Amyloid Angiopathy Cerebral Hemorrhage, Hereditary, With Amyloidosis, Icelandic Variant Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Variant Caa, Familial Cerebral Amyloid Angiopathy, Genetic Acys Amyloidosis Cst3-Related Amyloidosis Cystatin Amyloidosis Hchwa, Icelandic Type Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Type Amyloidosis 6 AMYL6 Acys Caa Cerebral Amyloid Angiopathy Cst3-Related Cerebroarterial Amyloidosis Icelandic Type Cystatin C Amyloidosis Hccaa Hchwai Hchwa-I Hereditary Cerebral Hemorrhage With Amyloidosis Icelandic Type Cerebral Amyloid Angiopathy Familial Angiopathy, Amyloid, Cerebral, Cst3-Related Hereditary Cerebral Amyloid Angiopathy, Icelandic Type Familial Cerebral Amyloid Angiopathy Cerebral Amyloid Angiopathy, Hereditary
Mild Cognitive Impairment
Subjective Cognitive Decline
Dementia, Lewy Body	Lewy Body Dementia Lewy Body Disease Diffuse Lewy Body Disease Dementia With Lewy Bodies DLB Autosomal Dominant Diffuse Lewy Body Disease Cortical Lewy Body Disease Dementia, Lewy Body, Susceptibility To Lewy Body Dementia, Susceptibility To Senile Dementia Of The Lewy Body Type Dementia Of The Lewy Body Type Lbd Diffuse Lewy Body Disease With Gaze Palsy Dysphasic Dementia Hereditary Lewy Body Type Senile Dementia Lewy Body Variant Of Alzheimer Disease Lewy Bodies Lewy Body Dlbd - [Diffuse Lewy Body Disease] Clbd - [Cortical Lewy Body Disease]
Supranuclear Palsy, Progressive, 1	Progressive Supranuclear Palsy Steele-Richardson-Olszewski Syndrome Supranuclear Palsy, Progressive Progressive Supranuclear Ophthalmoplegia Psp PSNP1 Familial Progressive Supranuclear Palsy Richardson'S Syndrome Psp Syndrome Progressive Supranuclear Palsy 1 Supranuclear Palsy Progressive Ophthalmoplegia, Supranuclear, Progressive Steele-Richardson-Olszewksi Syndrome
Cerebral Degeneration	Brain Degeneration Degenerative Brain Disorder
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-10227	Bortezomib		99.97%	Yes

Clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-W017540	Cyclocreatine	Activator	99.78%	Phase 1

Inhibitory Antibodies (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-P990043	Iluzanebart		98.63%	Phase 2
HY-P991734	VHB937		99.9%	Phase 2
HY-P990651	PY314	Inhibitor	96.35%	Phase 1

Pre-clinical Phase

Bioactive Molecules (19)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-P10136	IA9	Inhibitor	97.24%	Unkown
HY-160421	TREM2-IN-1	Inducer	99.34%	Unkown
HY-175510	TREM2 agonist-5	Agonist	99.61%	Unkown
HY-P10136A	IA9 TFA	Inhibitor	98.90%	Unkown
HY-174369	TREM2 agonist-3		99.39%	Unkown
HY-174378	TREM2 agonist-4	Inhibitor	99.81%	Unkown
HY-182702	As48		/	Unkown
HY-P991754	Anti-Mouse TREM2 Antibody (178)	Inhibitor	98.92%	Unkown
HY-RS16526	Trem2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-10227S	Bortezomib-d8		98.0%	Unkown
HY-169859	EP4 receptor antagonist 7	Antagonist	99.9%	Unkown
HY-178324	T2M-010		/	Unkown
HY-RS15003	TREM2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-182756	TREM2 modulator-1	Modulator	/	Unkown
HY-10227G	Bortezomib (GMP)		/	Unkown
HY-P10220	NOTA-COG1410	Ligand	/	Unkown
HY-W017540S	Cyclocreatine-13C3		/	Unkown
HY-N9164	Hecubine		/	Unkown
HY-RS22957	Trem2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (8)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-P991220	AL002	Agonist	98.01%	Unkown
HY-P991621	EOS006215	Inhibitor	98.47%	Unkown
HY-P991442	DNL-919 (Human IgG1)	Agonist	96.17%	Unkown
HY-P991174	Anti-TREM2 Antibody (AL2p-58)	Inhibitor	97.43%	Unkown
HY-P992118	Lifonebart	Inhibitor	99.9%	Unkown
HY-P992513	Anti-Mouse TREM2 Antibody (4D9)	Inhibitor	/	Unkown
HY-P991905	AL044		97.39%	Unkown
HY-P992516	DNL-919 (ATV)	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TREM2	VGNC	VGNC:79089
Felis catus	TREM2	VGNC	VGNC:66519
Rattus norvegicus	TREM2	RGD	RGD:1309841
Canis familiaris	TREM2	VGNC	VGNC:47794
Bos taurus	TREM2	VGNC	VGNC:36299
Mus musculus	TREM2	MGD	MGI:1913150
Others	TREM2	NCBI