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Cat. No.: HY-P992516

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DNL-919 (ATV)

DNL-919 ATV is a brain-penetrant TREM2 agonist. DNL-919 ATV induces responsive microglial cell state changes and modulates microglial biomarkers. DNL-919 ATV can be used for the research of Alzheimer's disease.

For research use only. We do not sell to patients.

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Please store the product under the recommended conditions in the Certificate of Analysis.

DNL-919 (ATV) Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

TREM-2

All TREM receptor Isoforms :

In Vitro

DNL-919 ATV exhibits robust target engagement and effects on microglial biomarkers (e.g., CSF1R, SPP1, IL1RA, IP10, MIP1b, MCP-1)^[1].
DNL-919 ATV increases phagocytic activity in human microglia cells^[2].
DNL-919 ATV causes anemia [2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Animals and Diseases

Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.

Purity & Documentation

Inhibitory Antibodies User Guide (603 KB)

References

[1]. Denali Therapeutics. Denali Therapeutics Reports Second Quarter 2023 Financial Results and Business Highlights. 2023 Aug 8.

[2]. Kraller M, Faßbender J, Jabali A, et al.. Novel fully human high-affinity anti-TREM2 antibody shows efficacy in clinically relevant Alzheimer´s mouse model. Alzheimer's research & therapy. 2025 May 22;17(1):114. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocols
Purity & Documentation
References

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DNL-919 (ATV)

Cytotoxicity LDH Assay Kit

DPBS Buffer (1×)

PBS Buffer (1×)

All TREM receptor Isoforms