Anti-Mouse TREM2 Antibody (4D9)
Based on 1 Customer Validation
Anti-Mouse TREM2 Antibody (4D9) is a monoclonal antibody targeting TREM2. Anti-Mouse TREM2 Antibody (4D9) enhances microglial signaling, induces reversible morphological changes in microglia, converts microglia into a metabolically responsive state, and increases the state diversity of microglia. Anti-Mouse TREM2 Antibody (4D9) can be used in studies related to Alzheimer's disease.
For research use only. We do not sell to patients.
- Purity : 97.42%
- Molecular Weight:147.02 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Isotype
Mouse IgG2a kappa
Recommend Isotype Controls
Species Reactivity
Mouse
IC50 & Target
[1]|
TREM-2 |
In Vitro
Anti-Mouse TREM2 Antibody (4D9) (ATV:4D9 complex) binds to mouse TREM2 protein with high affinity (Kd = 0.316 nM)[1].
Anti-Mouse TREM2 Antibody (4D9 (ATV:4D9 complex)) rescues the survival of bone marrow-derived macrophages from WT;TfRmu/hu mice under low M-CSF conditions, with an EC50 of 4.1 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:WT;TfRmu/hu (human TfR apical domain knock-in)[1]
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Dosage:10 mg/kg
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Administration:i.v.; single dose
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Result:Reached brain concentration of <1 nM.
Showed significantly lower brain concentration compared to ATV:4D9 (2-4 nM).
Gene ID
Accession
Q99NH8
Target
TREM-2
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Application
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized TREM-2 Protein, Human (HEK293, HY-P70534) can bind Anti-Mouse TREM2 Antibody (4D9). The ED50 for this effect is 2.029 ng/mL.
Chemical Information
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Appearance Liquid
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Molecular Weight 147.02 kDa
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Color Colorless to light yellow
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (260 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse TREM2 Antibody (4D9) Related Classifications
HY-P992513 Related Classifications
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