2. Immunology/Inflammation
  3. TREM receptor
  4. Anti-Mouse TREM2 Antibody (4D9)

Anti-Mouse TREM2 Antibody (4D9) is a monoclonal antibody targeting TREM2. Anti-Mouse TREM2 Antibody (4D9) enhances microglial signaling, induces reversible morphological changes in microglia, converts microglia into a metabolically responsive state, and increases the state diversity of microglia. Anti-Mouse TREM2 Antibody (4D9) can be used in studies related to Alzheimer's disease.

For research use only. We do not sell to patients.

Anti-Mouse TREM2 Antibody (4D9)

Anti-Mouse TREM2 Antibody (4D9) Chemical Structure

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Anti-Mouse TREM2 Antibody (4D9) Related Antibodies

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Description

Anti-Mouse TREM2 Antibody (4D9) is a monoclonal antibody targeting TREM2. Anti-Mouse TREM2 Antibody (4D9) enhances microglial signaling, induces reversible morphological changes in microglia, converts microglia into a metabolically responsive state, and increases the state diversity of microglia. Anti-Mouse TREM2 Antibody (4D9) can be used in studies related to Alzheimer's disease[1].

Isotype

Mouse IgG2a kappa
Recommend Isotype Controls
Species Reactivity

Mouse
IC50 & Target[1]

TREM-2

 

In Vitro

Anti-Mouse TREM2 Antibody (4D9) (ATV:4D9 complex) binds to mouse TREM2 protein with high affinity (Kd = 0.316 nM)[1].
Anti-Mouse TREM2 Antibody (4D9 (ATV:4D9 complex)) rescues the survival of bone marrow-derived macrophages from WT;TfRmu/hu mice under low M-CSF conditions, with an EC50 of 4.1 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse TREM2 Antibody (4D9) Related Antibodies
In Vivo

Anti-Mouse TREM2 Antibody (4D9) (10 mg/kg; i.v.; single dose) shows low brain exposure ( <1 nM) 1 day after a single 10 mg/kg intravenous dose in WT;TfRmu/hu mice, with significantly lower brain concentration compared to ATV:4D9[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: WT;TfRmu/hu (human TfR apical domain knock-in)[1]
Dosage: 10 mg/kg
Administration: i.v.; single dose
Result: Reached brain concentration of <1 nM.
Showed significantly lower brain concentration compared to ATV:4D9 (2-4 nM).
Gene ID

83433  [NCBI]

Accession

Q99NH8
Target

TREM-2
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-Mouse TREM2 Antibody (4D9) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse TREM2 Antibody (4D9)TREM receptorTriggering receptors expressed on myeloid cellsalzheimer’s diseasehuman TREM2blood-brain barrierhuman TfR proteinsWT;TfRmu/hu mouse bone marrow-derived macrophagesWT;TfRmu/hu micecerebrospinal fluidmouse TREM2AppSAA;TfRmu/hu Alzheimer's disease micemicrogliaInhibitorinhibitorinhibit

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Anti-Mouse TREM2 Antibody (4D9)
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