country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-P992513

Copy Link Print Information

Anti-Mouse TREM2 Antibody (4D9)

Name: Anti-Mouse TREM2 Antibody (4D9)
Brand: MedChemExpress
SKU: HY-P992513
Price: 400.00 USD
Availability: InStock
Rating: 5 (1 reviews)

Customer Review

Based on 1 Customer Validation

Anti-Mouse TREM2 Antibody (4D9) is a monoclonal antibody targeting TREM2. Anti-Mouse TREM2 Antibody (4D9) enhances microglial signaling, induces reversible morphological changes in microglia, converts microglia into a metabolically responsive state, and increases the state diversity of microglia. Anti-Mouse TREM2 Antibody (4D9) can be used in studies related to Alzheimer's disease.

For research use only. We do not sell to patients.

Purity: 97.42%

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Anti-Mouse TREM2 Antibody (4D9) Chemical Structure

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Anti-Mouse TREM2 Antibody (4D9) Product Recommendations:

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Application
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Isotype

Mouse IgG2a kappa

Recommend Isotype Controls

Mouse IgG2a kappa, Isotype Control

Species Reactivity

Mouse

IC₅₀ & Target^[1]

TREM-2

All TREM receptor Isoforms :

In Vitro

Anti-Mouse TREM2 Antibody (4D9) (ATV:4D9 complex) binds to mouse TREM2 protein with high affinity (K_d = 0.316 nM)^[1].
Anti-Mouse TREM2 Antibody (4D9 (ATV:4D9 complex)) rescues the survival of bone marrow-derived macrophages from WT;TfRmu/hu mice under low M-CSF conditions, with an EC₅₀ of 4.1 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anti-Mouse TREM2 Antibody (4D9) (10 mg/kg; i.v.; single dose) shows low brain exposure ( <1 nM) 1 day after a single 10 mg/kg intravenous dose in WT;TfRmu/hu mice, with significantly lower brain concentration compared to ATV:4D9^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

WT;TfRmu/hu (human TfR apical domain knock-in)^[1]
Dosage:

10 mg/kg
Administration:

i.v.; single dose
Result:

Reached brain concentration of <1 nM.
Showed significantly lower brain concentration compared to ATV:4D9 (2-4 nM).

Gene ID

83433 [NCBI]

Accession

Q99NH8

Target

TREM-2

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Application

ELISA, FACS, Functional assay

Chemical Information

Appearance Liquid
Color Colorless to light yellow
Shipping

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (259 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

References

[1]. van Lengerich B, et al. A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models. Nat Neurosci. 2023 Mar;26(3):416-429. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote

Amount: USD 0.00

Biological Activity
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Application
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

Anti-Mouse TREM2 Antibody (4D9)

Cytotoxicity LDH Assay Kit

DPBS Buffer (1×)

PBS Buffer (1×)

All TREM receptor Isoforms