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Onartuzumab

(Synonyms: MetMAb)
2 Cited Publications
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Based on 2 publication(s) in Google Scholar

Onartuzumab (MetMAb) is a unique, humanized and affinity-matured monovalent (one-armed) monoclonal antibody against the MET receptor. Onartuzumab potently inhibits HGF binding and receptor phosphorylation and signaling. Onartuzumab has antibody-like pharmacokinetics and antitumor activity.

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  • Reinheit: 99.62%
  • CAS. Nr.: 1133766-06-9
  • Molecular Weight:98.907 kDa
  • Speicherung:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Onartuzumab
  • Experimental Validation Results for Onartuzumab
  • Experimental Validation Results for Onartuzumab
  • Onartuzumab Chemical Structure
    Onartuzumab Chemical Structure
CAS. Nr.: 1133766-06-9
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Assay Types
  • 1/16

    (Fab-G1-kappa)-(Fc-G1)

  • 1/16

    Immobilized Onartuzumab can bind Human c-MET/HGFR Protein (ECD, His Tag). The EC50 for this effect is 4.21 ng/mL.

  • 1/16

    Flow cytometric analysis of 1.5×106 MDA-MB-231 cells with Onartuzumab (HY-P99250, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Onartuzumab Chemical Structure
    1/16
  • Onartuzumab
  • Immobilized Onartuzumab can bind Human c-MET/HGFR Protein (ECD, His Tag). The EC50 for this effect is 4.21 ng/mL.
  • Flow cytometric analysis of 1.5×106 MDA-MB-231 cells with Onartuzumab (HY-P99250, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • (Fab-G1-kappa)-(Fc-G1)