PDE1-IN-4
PDE1-IN-4 (compound 2g) is a potent and selective PDE1 (phosphodiesterase-1) inhibitor, with IC50 values of 10, 145, and 354 nM for PDE1C, PDE1A, and PDE1B, respectively. PDE1-IN-4 inhibits myofibroblast differentiation of human lung fibroblasts induced by TGF-β1. PDE1-IN-4 shows anti-fibrosis effects through the regulation of cAMP (3′,5′-cyclic adenosine monophosphate) and cGMP (3′,5′-cyclic guanosine monophosphate). PDE1-IN-4 can be used for idiopathic pulmonary fibrosis (IPF) research.
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- CAS. Nr.: 3031349-98-8
- Formel: C33H33N3O4
- Molecular Weight:535.63
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
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Help & FAQs
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Biologische Aktivität
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PDE1C 10 ± 3 nM (IC50) |
PDE1A 145 nM (IC50) |
PDE1B 354 nM (IC50) |
PDE4B2 619 nM (IC50) |
PDE4D2 948 nM (IC50) |
PDE10A 1310 nM (IC50) |
PDE5A1 1810 nM (IC50) |
PDE2A 5130 nM (IC50) |
PDE3A >10000 nM (IC50) |
PDE9A2 >10000 nM (IC50) |
PDE1-IN-4 (compound 2g) shows weak inhibition against the hERG channel with an IC50 above 40 μM, indicating that it will not cause cardiotoxicity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 3031349-98-8
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Molecular Weight 535.63
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Formel C33H33N3O4
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SMILES
CC1=C(C(C2=CC3=C(C=C2)N(N=C3)C)C(C(O[C@@H](C4=CC=CC=C4)C)=O)=C(N1)C)C(O[C@@H](C5=CC=CC=C5)C)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
PDE1-IN-4 Related Classifications
HY-147946 Related Classifications
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