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Art. -Nr.: HY-152080A

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(R)-Blovacitinib

(Synonyms: (R)-TUL01101)

(R)-Blovacitinib ((R)-TUL01101) is a JAK1-selective inhibitor with an IC₅₀ of 45 nM. (R)-Blovacitinib inhibits JAK1-mediated cytokine signaling pathways. (R)-Blovacitinib can be used for the research of rheumatoid arthritis.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2411222-96-1
Formel: C₂₂H₂₅F₂N₅O₂
Molecular Weight:429.46

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

(R)-Blovacitinib Chemical Structure

CAS. Nr.: 2411222-96-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
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Calculators
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Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

JAK1

45 nM (IC₅₀)

Alle JAK Isoform-spezifische Produkte anzeigen :

In Vitro

(R)-Blovacitinib (compound 35) inhibits purified human JAK1 with an IC₅₀ of 45 nM, showing 11.7-fold selectivity over JAK2 and 8.0-fold selectivity over TYK2, with no significant inhibition of JAK3^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2411222-96-1
Molecular Weight 429.46
Formel C₂₂H₂₅F₂N₅O₂
SMILES

O=C([C@@H]1C(F)(C1)F)N2CC3(CCC(C4=CC=CC5=NC(NC(C6CC6)=O)=NN45)CC3)C2
Synonyms

(R)-TUL01101
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Zhou S, et al. Identification of TUL01101: A Novel Potent and Selective JAK1 Inhibitor for the Treatment of Rheumatoid Arthritis. Journal of medicinal chemistry. 2022 Dec 22;65(24):16716-16740. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
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- IC₅₀ & Target
- In Vitro
Chemical Information
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(R)-Blovacitinib

Alle JAK Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

(R)-Blovacitinib Related Classifications

HY-152080A Related Classifications