Etanercept
Based on 15 publication(s) in Google Scholar
Etanercept, a dimeric fusion protein that binds TNF, acts as a TNF inhibitor. Etanercept competitively inhibits the binding of both TNF-α and TNF-β to cell surface TNF receptors, rendering TNF biologically inactive. Etanercept shows efficacy against rheumatoid arthritis, juvenile idiopathic arthritis, and plaque psoriasis.
For research use only. We do not sell to patients.
- Purity: 99.20%
- CAS No.: 185243-69-0
- Molecular Weight:102.5 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Etanercept
More- Bone Res. 2024 May 23;12(1):31. [Abstract]
- Int J Oral Sci. 2026 Mar 1;18(1):22. [Abstract]
- Genes Dis. 2022 Jun 20;10(4):1552-1563. [Abstract]
- J Neuroinflammation. 2025 Nov 1;22(1):256. [Abstract]
- Cell Rep. 2025 Feb 18;44(2):115287. [Abstract]
- JCI Insight. 2025 Nov 24;10(22):e190836. [Abstract]
- World J Stem Cells. 2022 Nov 26;14(11):798-814. [Abstract]
- iScience. 2024 Apr 26;27(6):109798. [Abstract]
- Clin Exp Immunol. 2023 Dec 11;214(1):120-129. [Abstract]
- J Pharm Biomed Anal. 2026 Mar 15:270:117273. [Abstract]
- Psychopharmacology (Berl). 2025 Oct 24. [Abstract]
- J Pain Res. 2025 Nov 12:18:6057-6063. [Abstract]
- Scand J Immunol. 2025 May;101(5):e70033. [Abstract]
- bioRxiv. 2025 Sep 12.
- SSRN. 2023 Nov 28.
Customer Validation & Images
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In Vivo Efficacy Study
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In Vivo Imaging
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Histological Imaging/Staining
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In Vivo Efficacy Study
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IF
Biological Activity
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Fas |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Six-week-old male Lewis rats (adjuvant-induced arthritis (AIA) model)[4]
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Dosage:10 mg/kg
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Administration:S.c.; every 3 days for 3 weeks
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Result:Significantly decreased the mean arthritis scores; Significant decreased in radiological score at the end of the treatment period.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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[TNFRSF1B (tumor necrosis factor receptor (TNFR)superfamily member 1B, TNFBR, p75, CD120b)]2-IGHG1 Fc (Fragment constant)
ELISA, FACS, Functional assay
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Immobilized TNF-alpha/TNFSF2 Protein, Human (His, HY-P7416) can bind Etanercept. The EC50 for this effect is 9.44 ng/mL.
Chemical Information
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CAS No. 185243-69-0
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Appearance Liquid
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Molecular Weight 102.5 kDa
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Color Colorless to light yellow
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SMILES
[Etanercept]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (15)
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Journal Impact Factor
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Most Recent
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Bone Res
Gut microbial metabolite targets HDAC3-FOXK1-interferon axis in fibroblast-like synoviocytes to ameliorate rheumatoid arthritis. [Abstract]2024 May 23;12(1):31. PMID: 38782893
Etanercept purchased from MedChemExpress. Usage Cited in: Bone Res. 2024 May 23;12(1):31. [Abstract]
Evaluation of arthritis scores for non-immunized (NI) mice or CIA mice in different treatment groups. Etanercept (i.p., 5 mg/kg) twice every week for 5 weeks.
Etanercept purchased from MedChemExpress. Usage Cited in: Bone Res. 2024 May 23;12(1):31. [Abstract]
Representative micro-CT images of the mice in different groups. Etanercept (i.p., 5 mg/kg) twice every week for 5 weeks.
Etanercept purchased from MedChemExpress. Usage Cited in: Bone Res. 2024 May 23;12(1):31. [Abstract]
Images of H&E and SafO-FG staining of the paw sections. Etanercept (i.p., 5 mg/kg) twice every week for 5 weeks.
Etanercept purchased from MedChemExpress. Usage Cited in: Bone Res. 2024 May 23;12(1):31. [Abstract]
Measurement of BS/BV, and quantification of synovial inflammation and bone erosion on H&E-stained sections, as well as cartilage erosion on SafO-FG-stained sections. Etanercept (i.p., 5 mg/kg) twice every week for 5 weeks.
Etanercept purchased from MedChemExpress. Usage Cited in: Bone Res. 2024 May 23;12(1):31. [Abstract]
Immunofluorescence staining of FOXK1, STAT1, STAT2, IL-6, IL-1β and MMP3 on sections of paws of the mice in different groups. Etanercept (i.p., 5 mg/kg) twice every week for 5 weeks.
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Int J Oral Sci
Single-cell transcriptional atlas reveals distinct immune-chondrocyte crosstalk mechanisms in temporomandibular joint osteoarthritis induced by different types of occlusal disorder. [Abstract]2026 Mar 1;18(1):22. PMID: 41764220 -
Genes Dis
Protective effects of IRG1/itaconate on acute colitis through the inhibition of gasdermins-mediated pyroptosis and inflammation response. [Abstract]2022 Jun 20;10(4):1552-1563. PMID: 37397544 -
J Neuroinflammation
Inflammation associated microglial expansion disrupts hippocampal glial network communication, driving postoperative neurocognitive impairment. [Abstract]2025 Nov 1;22(1):256. PMID: 41176600 -
Cell Rep
Glycolytic reprogramming shapes the histone acetylation profile of activated CD4+ T cells in juvenile idiopathic arthritis. [Abstract]2025 Feb 18;44(2):115287. PMID: 40009514 -
JCI Insight
TNF-α represses fibroblast to myofibroblast transition through the histone methyltransferase Setdb2. [Abstract]2025 Nov 24;10(22):e190836. PMID: 41277557 -
World J Stem Cells
Tumor necrosis factor-α inhibition restores matrix formation by human adipose-derived stem cells in the late stage of chondrogenic differentiation. [Abstract]2022 Nov 26;14(11):798-814. PMID: 36483847 -
iScience
GSK2334470 attenuates high salt-exacerbated rheumatoid arthritis progression by restoring Th17/Treg homeostasis. [Abstract]2024 Apr 26;27(6):109798. PMID: 38947509 -
Clin Exp Immunol
NRF1 knockdown alleviates lipopolysaccharide-induced pulmonary inflammatory injury by upregulating DKK3 and inhibiting the GSK-3β/β-catenin pathway. [Abstract]2023 Dec 11;214(1):120-129. PMID: 37402316 -
J Pharm Biomed Anal
Leveraging digestion-assisted capillary electrophoresis sodium dodecyl sulfate (CE-SDS) to monitor galactosylation in monoclonal antibodies. [Abstract]2026 Mar 15:270:117273. PMID: 41275721 -
Psychopharmacology (Berl)
Agmatine ameliorates morphine-induced behavioral sensitization through blood-brain barrier protection and anti-neuroinflammatory effects in the nucleus accumbens. [Abstract]2025 Oct 24. PMID: 41134339 -
J Pain Res
2025 Nov 12:18:6057-6063. PMID: 41257213 -
Scand J Immunol
The Fusion Protein MuSK-Fc Functions as a Decoy to Block the Binding of Anti-MuSK Antibodies to MuSK. [Abstract]2025 May;101(5):e70033. PMID: 40411208 -
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Purity & Documentation
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Data Sheet (261 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Goffe B, et al. Etanercept: An overview. J Am Acad Dermatol. 2003;49(2 Suppl):S105-S111. [Content Brief]
[2]. Goldenberg MM. Etanercept, a novel drug for the treatment of patients with severe, active rheumatoid arthritis. Clin Ther. 1999;21(1):75-2. [Content Brief]
[3]. Haraoui B, et al. Etanercept in the treatment of rheumatoid arthritis. Ther Clin Risk Manag. 2007;3(1):99-105. [Content Brief]
[4]. Totoson P, et al. Etanercept improves endothelial function via pleiotropic effects in rat adjuvant-induced arthritis. Rheumatology (Oxford). 2016;55(7):1308-1317. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Etanercept Related Classifications
HY-108847 Related Classifications
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