1. Protein Tyrosine Kinase/RTK
    Apoptosis
  2. FLT3
    Apoptosis
  3. ATH686

ATH686 

Cat. No.: HY-15003
Handling Instructions

ATH686 is a potent, selective and ATP-competitive FLT3 inhibitor. ATH686 target mutant FLT3 protein kinase activity and inhibit the proliferation of cells harboring FLT3 mutants via induction of apoptosis and cell cycle inhibition. ATH686 has antileukemic effects.

For research use only. We do not sell to patients.

ATH686 Chemical Structure

ATH686 Chemical Structure

CAS No. : 853299-52-2

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Description

ATH686 is a potent, selective and ATP-competitive FLT3 inhibitor. ATH686 target mutant FLT3 protein kinase activity and inhibit the proliferation of cells harboring FLT3 mutants via induction of apoptosis and cell cycle inhibition. ATH686 has antileukemic effects[1].

In Vitro

ATH686 (1-100 µM; 3 days) potently inhibits cell proliferation (IC50 around 0.001 µM) via induction of apoptosis in FLT3-ITD-Ba/F3 cells and D835Y-Ba/F3 cells[1].
ATH686 (10 nM; for 15 minutes) inhibits autophosphorylation of mutant FLT3 in FLT3-ITD-Ba/F3 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: FLT3-ITD-Ba/F3 cells and D835Y-Ba/F3 cells
Concentration: 1, 5, 10, 50, 100 µM
Incubation Time: 3 days
Result: Potently inhibited cell proliferation (IC50 around 0.001 µM) via induction of apoptosis.

Western Blot Analysis[1]

Cell Line: FLT3-ITD-Ba/F3 cells
Concentration: 10 nM
Incubation Time: For 15 minutes
Result: Inhibited autophosphorylation of mutant FLT3, with no apparent reduction in levels of the FLT3 protein.
Molecular Weight

515.53

Formula

C₂₅H₂₈F₃N₇O₂

CAS No.

853299-52-2

SMILES

NC1=NC(OC2=CC=C(NC(NC3=CC(C(F)(F)F)=C(CN4CCN(CC)CC4)C=C3)=O)C=C2)=CC=N1

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

ATH686ATH 686ATH-686FLT3ApoptosisCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3ATP-competitiveantileukemicautophosphorylationInhibitorinhibitorinhibit

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ATH686
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HY-15003
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