1. Protein Tyrosine Kinase/RTK
    Apoptosis
  2. FLT3
    Apoptosis
  3. ATH686

ATH686 

Cat. No.: HY-15003 Purity: 99.58%
Handling Instructions

ATH686 is a potent, selective and ATP-competitive FLT3 inhibitor. ATH686 target mutant FLT3 protein kinase activity and inhibit the proliferation of cells harboring FLT3 mutants via induction of apoptosis and cell cycle inhibition. ATH686 has antileukemic effects.

For research use only. We do not sell to patients.

ATH686 Chemical Structure

ATH686 Chemical Structure

CAS No. : 853299-52-2

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 454 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 454 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 400 In-stock
Estimated Time of Arrival: December 31
10 mg USD 680 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1350 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2200 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

ATH686 is a potent, selective and ATP-competitive FLT3 inhibitor. ATH686 target mutant FLT3 protein kinase activity and inhibit the proliferation of cells harboring FLT3 mutants via induction of apoptosis and cell cycle inhibition. ATH686 has antileukemic effects[1].

In Vitro

ATH686 (1-100 µM; 3 days) potently inhibits cell proliferation (IC50 around 0.001 µM) via induction of apoptosis in FLT3-ITD-Ba/F3 cells and D835Y-Ba/F3 cells[1].
ATH686 (10 nM; for 15 minutes) inhibits autophosphorylation of mutant FLT3 in FLT3-ITD-Ba/F3 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: FLT3-ITD-Ba/F3 cells and D835Y-Ba/F3 cells
Concentration: 1, 5, 10, 50, 100 µM
Incubation Time: 3 days
Result: Potently inhibited cell proliferation (IC50 around 0.001 µM) via induction of apoptosis.

Western Blot Analysis[1]

Cell Line: FLT3-ITD-Ba/F3 cells
Concentration: 10 nM
Incubation Time: For 15 minutes
Result: Inhibited autophosphorylation of mutant FLT3, with no apparent reduction in levels of the FLT3 protein.
Molecular Weight

515.53

Formula

C₂₅H₂₈F₃N₇O₂

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (484.94 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9398 mL 9.6988 mL 19.3975 mL
5 mM 0.3880 mL 1.9398 mL 3.8795 mL
10 mM 0.1940 mL 0.9699 mL 1.9398 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.03 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.03 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.03 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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ATH686
Cat. No.:
HY-15003
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