CB1R Allosteric modulator 3
Based on 1 Customer Validation
CB1R Allosteric modulator 3 is a CB1R positive allosteric modulator. CB1R Allosteric modulator 3 has potent inhibition of cAMP and β-Arrestin with EC50 values of 0.018 μM and 1.241 μM, respectively.
For research use only. We do not sell to patients.
- Purity: 98.05%
- CAS No.: 2633686-36-7
- Formula: C22H17ClN2O2
- Molecular Weight:376.84
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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CB1 |
CB1R Allosteric modulator 3 (compound 44) (0.10 nM-10 μM, 30 min) has potent inhibition of cAMP and β-Arrestin with EC50 values of 0.018 μM and 1.241 μM, respectively[1].
CB1R Allosteric modulator 3 can enhance CB1R ago-PAM activity because of small lipophilic functional groups on the ortho-position of the GAT211 site-III phenyl ring[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2633686-36-7
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Appearance Solid
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Molecular Weight 376.84
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Formula C22H17ClN2O2
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Color Off-white to light yellow
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SMILES
ClC1=C(C=CC=C1)C(C2=C(C3=CC=CC=C3)NC4=C2C=CC=C4)C[N+]([O-])=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (265.36 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (283 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Peter C Schaffer, et al. Focused structure-activity relationship profiling around the 2-phenylindole scaffold of a cannabinoid type-1 receptor agonist-positive allosteric modulator: site-III aromatic-ring congeners with enhanced activity and solubility. Bioorg Med Chem. 2020 Nov 1;28(21):115727. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6536 mL | 13.2682 mL | 26.5365 mL | 66.3412 mL |
| 5 mM | 0.5307 mL | 2.6536 mL | 5.3073 mL | 13.2682 mL | |
| 10 mM | 0.2654 mL | 1.3268 mL | 2.6536 mL | 6.6341 mL | |
| 15 mM | 0.1769 mL | 0.8845 mL | 1.7691 mL | 4.4227 mL | |
| 20 mM | 0.1327 mL | 0.6634 mL | 1.3268 mL | 3.3171 mL | |
| 25 mM | 0.1061 mL | 0.5307 mL | 1.0615 mL | 2.6536 mL | |
| 30 mM | 0.0885 mL | 0.4423 mL | 0.8845 mL | 2.2114 mL | |
| 40 mM | 0.0663 mL | 0.3317 mL | 0.6634 mL | 1.6585 mL | |
| 50 mM | 0.0531 mL | 0.2654 mL | 0.5307 mL | 1.3268 mL | |
| 60 mM | 0.0442 mL | 0.2211 mL | 0.4423 mL | 1.1057 mL | |
| 80 mM | 0.0332 mL | 0.1659 mL | 0.3317 mL | 0.8293 mL | |
| 100 mM | 0.0265 mL | 0.1327 mL | 0.2654 mL | 0.6634 mL |
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