2633686-36-7
2633686-36-7
Chemical Structure
CB1R Allosteric modulator 3
- CAS No.: 2633686-36-7
- Formula:C22H17ClN2O2
- Molecular Weight:376.84
IUPAC Name: 3-(1-(2-chlorophenyl)-2-nitroethyl)-2-phenyl-1H-indole
InChIKey: FWEGGBUXRLCEQI-UHFFFAOYSA-N
SMILES: ClC1=C(C=CC=C1)C(C2=C(C3=CC=CC=C3)NC4=C2C=CC=C4)C[N+]([O-])=O
Biological Activity: CB1R Allosteric modulator 3 is a CB1R positive allosteric modulator. CB1R Allosteric modulator 3 has potent inhibition of cAMP and β-Arrestin with EC50 values of 0.018 μM and 1.241 μM, respectively[1].
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CB1R Allosteric modulator 3 | 98.05% | CB1R Allosteric modulator 3 is a CB1R positive allosteric modulator. CB1R Allosteric modulator 3 has potent inhibition of cAMP and β-Arrestin with EC50 values of 0.018 μM and 1.241 μM, respectively. | ||||||||||||||||||||
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References
- [1]. Peter C Schaffer, et al. Focused structure-activity relationship profiling around the 2-phenylindole scaffold of a cannabinoid type-1 receptor agonist-positive allosteric modulator: site-III aromatic-ring congeners with enhanced activity and solubility. Bioorg Med Chem. 2020 Nov 1;28(21):115727. [Content Brief]
