COX-1-IN-3
Based on 1 Customer Validation
COX-1-IN-3 (compound 19) is a COX-1 inhibitor with non-steroidal anti-inflammatory activity.
For research use only. We do not sell to patients.
- Purity: 99.95%
- CAS No.: 20170-32-5
- Formula: C17H26O3
- Molecular Weight:278.39
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Storage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Anti-Aging Compound Library
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Biological Activity
COX-1[1]
Chemical Information
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CAS No. 20170-32-5
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Appearance Solid
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Molecular Weight 278.39
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Formula C17H26O3
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Color White to off-white
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SMILES
O=C(O)CCC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
DMSO : 100 mg/mL (359.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (271 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. StarRibeiro D, et al. New phenolic cinnamic acid derivatives as selective COX-2 inhibitors. Design, synthesis, biological activity and structure-activity relationships. Bioorg Chem. 2019 Oct;91:103179.cević S, et al. Synthesis and biological evaluation of (6- and 7-phenyl) coumarin derivatives as selective nonsteroidal inhibitors of 17β-hydroxysteroid dehydrogenase type 1. J Med Chem. 2011 Jan 13;54(1):248-61. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5921 mL | 17.9604 mL | 35.9208 mL | 89.8021 mL |
| 5 mM | 0.7184 mL | 3.5921 mL | 7.1842 mL | 17.9604 mL | |
| 10 mM | 0.3592 mL | 1.7960 mL | 3.5921 mL | 8.9802 mL | |
| 15 mM | 0.2395 mL | 1.1974 mL | 2.3947 mL | 5.9868 mL | |
| 20 mM | 0.1796 mL | 0.8980 mL | 1.7960 mL | 4.4901 mL | |
| 25 mM | 0.1437 mL | 0.7184 mL | 1.4368 mL | 3.5921 mL | |
| 30 mM | 0.1197 mL | 0.5987 mL | 1.1974 mL | 2.9934 mL | |
| 40 mM | 0.0898 mL | 0.4490 mL | 0.8980 mL | 2.2451 mL | |
| 50 mM | 0.0718 mL | 0.3592 mL | 0.7184 mL | 1.7960 mL | |
| 60 mM | 0.0599 mL | 0.2993 mL | 0.5987 mL | 1.4967 mL | |
| 80 mM | 0.0449 mL | 0.2245 mL | 0.4490 mL | 1.1225 mL | |
| 100 mM | 0.0359 mL | 0.1796 mL | 0.3592 mL | 0.8980 mL |
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