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Cat. No.: HY-107834R

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PIK-75 (Standard)

PIK-75 (Standard) is the analytical standard of PIK-75 (HY-107834). This product is intended for research and analytical applications. PIK-75 is a reversible DNA-PK and p110α-selective inhibitor, which inhibits DNA-PK, p110α and p110γ with IC₅₀s of 2, 5.8 and 76 nM, respectively. PIK-75 inhibits p110α >200-fold more potently than p110β (IC₅₀=1.3 μM). PIK-75 induces apoptosis.

For research use only. We do not sell to patients.

CAS No.: 372196-67-3
Formula: C₁₆H₁₄BrN₅O₄S
Molecular Weight:452.28

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PIK-75 (Standard) Chemical Structure

CAS No.: 372196-67-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

IC₅₀ & Target

IC50: 2 nM (DNA-PK), 5.8 nM (p110α), 76 nM (p110γ), 510 nM (p110δ), ~1 μM (PI3KC2β), ~1 μM (mTORC1), 1.3 μM (p110β), 2.3 μM (ATM), 2.6 μM (hsVPS34), ~10 μM (PI3KC2α), ~10 μM (mTORC2), ~50 μM (PI4KIIIβ), 21 μM (ATR)^[1]

All PI3K Isoforms :

Chemical Information

CAS No. 372196-67-3
Molecular Weight 452.28
Formula C₁₆H₁₄BrN₅O₄S
SMILES

O=S(C1=CC([N+]([O-])=O)=CC=C1C)(N(C)/N=C/C2=CN=C3C=CC(Br)=CN32)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Knight ZA, et al. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell. 2006 May 19;125(4):733-47. [Content Brief]

[2]. Chaussade C, et al. Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling. Biochem J. 2007 Jun 15;404(3):449-58. [Content Brief]

[3]. Duong HQ, et al. Inhibition of NRF2 by PIK-75 augments sensitivity of pancreatic cancer cells to gemcitabine. Int J Oncol. 2014 Mar;44(3):959-69. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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PIK-75 (Standard)

All PI3K Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PIK-75 (Standard) Related Classifications

HY-107834R Related Classifications