Ro 10-5824
Based on 2 publication(s) in Google Scholar
Ro 10-5824 is a potent and selective D4R partial agonist with a Ki of 5.2 nM. Ro 10-5824 increases novel object exploration in C57 mice.
For research use only. We do not sell to patients.
- CAS No.: 189744-46-5
- Formula: C17H20N4
- Molecular Weight:280.38
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications Citing Use of MedChemExpress (MCE) Ro 10-5824
MoreAll Dopamine Receptor Isoforms
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Biological Activity
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Dopamine D4 receptor |
Chemical Information
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CAS No. 189744-46-5
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Molecular Weight 280.38
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Formula C17H20N4
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SMILES
N=1C=C(C(=NC1C)N)CN2CC=C(C=3C=CC=CC3)CC2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Br J Pharmacol
Requirement of sigma-1 receptor (Sig-1R) for boosting the gamma oscillations in the medial prefrontal cortex (mPFC). [Abstract]2026 Aug;183(15):4178-4195. PMID: 42025290 -
Brain Behav Immun
Neural network disturbance in the medial prefrontal cortex might contribute to cognitive impairments induced by neuroinflammation. [Abstract]2020 Oct;89:133-144. PMID: 32505714
Purity & Documentation
References
[1]. Powell SB, et al. RO-10-5824 is a selective dopamine D4 receptor agonist that increases novel object exploration in C57 mice. Neuropharmacology. 2003 Mar;44(4):473-81. [Content Brief]
[2]. Cummings DF, et al. Transmembrane segment five serines of the D4 dopamine receptor uniquely influence the interactions of dopamine, norepinephrine, and Ro10-4548. J Pharmacol Exp Ther. 2010 Jun;333(3):682-95. [Content Brief]
Calculators
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