Transketolase
Transketolase
Transketolase is a key rate-limiting enzyme in the non-oxidative branch of the pentose phosphate pathway (PPP). Transketolase is critical for energy transduction and for generating ribose for nucleic acid synthesis. Transketolase can convert ribulose 5-phosphate back into glucose 6-phosphate to generate more NADPH, and the reaction is thiamine-dependent. Transketolase has three isomer: TKT, TKTL1 and TKTL2. TKT is expressed in all investigated organisms, and is up-regulated in multiple cancer types[1][2].
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Transketolase Produits associés (14)
Produits associés (14)
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N3PT
0 ImagesSynonyms: N3-pyridyl thiamineN3PT (N3-pyridyl thiamine) is a potent and selective transketolase inhibitor. N3PT is pyrophosphorylated and then binds to transketolase with an Kd value of 22 nM (Apo-TK, transketolase lacking bound thiamine).
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α-Glycerophosphate Dehydrogenase-Triosephosphate
0 ImagesCat. No.: HY-E70075Synonyms: GDH-TIM; GDH-TPIα-Glycerophosphate Dehydrogenase-Triosephosphate (GDH-TIM) is an enzyme mixture composed of glycerol phosphate dehydrogenase (GDH) and triphosphate isomerase (TIM). α-Glycerophosphate Dehydrogenase-Triosephosphate can be used to determine the activity of transketolase (TK) in hemolytic substances of red blood cells to evaluate vitamin B deficiency.
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Oxythiamine diphosphate ammonium
0 ImagesCat. No.: HY-112889BPureté: 98.42%Oxythiamin diphosphate ammonium is a potent transketolase (TK) inhibitor.
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Transketolase-IN-1
0 ImagesTransketolase-IN-1 is a transketolase inhibitor and a herbicide. Transketolase-IN-1 inhibits weed growth and exhibits safety for maize and wheat at specified application rates. Transketolase-IN-1 can be used for the research of weed control in wheat and maize fields.
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Transketolase-IN-3
0 ImagesTransketolase-IN-3 is a potent transketolase (TK) inhibitor. Transketolase-IN-3 has herbicidal activity and has inhibitory effects against Digitaria sanguinalis (DS) and Amaranthus retroflexus (AR). Transketolase-IN-3 can be used for the research of herbicides.
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Transketolase-IN-2
0 ImagesTransketolase-IN-2 (compound 4w) is a potent Transketolase inhibitor. Transketolase-IN-2 shows strong inhibition of Digitaria sanguinalis and Amaranthus retroflexus (over 90% at 200 mg/L and about 80% at 100 mg/L). Transketolase-IN-2 can be used in studies of weed control.
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Transketolase-IN-4
0 ImagesTransketolase-IN-4 is a potent inhibitor of transketolase with an IC50 value of 3.9 μM. Transketolase-IN-4 inhibits the proliferation of tumor cells including SW620, LS174T and MIA PaCa-2. Transketolase-IN-4 can be used for tumor research.
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Oxythiamine diphosphate
0 ImagesCat. No.: HY-112889CAS No.: 10497-04-8Oxythiamin diphosphate is a potent transketolase (TK) inhibitor.
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Thiamine diphosphate analog 1
0 ImagesThiamine diphosphate analog 1 is an analog of thiamine diphosphate. Thiamine diphosphate is the active metabolite of vitamin B1 in organisms. Thiamine diphosphate targets ThDP-dependent enzymes such as transketolase and pyruvate dehydrogenase complex, acting as an essential coenzyme to exert an activating effect. Thiamine diphosphate assists in catalytic reactions in free form and initiates the catalytic cycles of various glucose-metabolizing enzymes. Thiamine diphosphate serves as a diagnostic biomarker and protective factor for Alzheimer's disease. Thiamine diphosphate can be used in research related to metabolism and Alzheimer's disease.
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TKL-IN-1
0 ImagesCat. No.: HY-170784TKL-IN-1 (compound 7r) is a transketolase inhibitor and can be used as a herbicide. TKL-IN-1 can inhibit the growth of Digitaria sanguinalis (Ds) and Amaranthus retroflexus (Ar).
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Transketolase-IN-6
0 ImagesCat. No.: HY-163311Transketolase-IN-6 is a potent transketolase inhibitor and a herbicide. Transketolase-IN-6 inhibits root growth of Digitaria sanguinalis, Amaranthus retroflexus, and Setaria viridis. Transketolase-IN-6 shows low phytotoxicity to wheat, maize, soybean, and cotton. Transketolase-IN-6 can be used for the research of herbicidal agent development.
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Transketolase-IN-5
0 ImagesCat. No.: HY-163310Transketolase-IN-5 is a transketolase inhibitor and a herbicide. Transketolase-IN-5 inhibits growth of Digitaria sanguinalis, Amaranthus retroflexus, and Setaria viridis.
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Herbicidal agent 6
0 ImagesCat. No.: HY-169168CAS No.: 3094190-09-4Herbicidal agent 6 (D15) is a Transketolase (TKL) inhibitor with herbicidal activity.
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Transketolase-IN-7
0 ImagesCat. No.: HY-180202Transketolase-IN-7 (compound 4m) is a potent herbicide that exhibits inhibitory activity against C. rotundus with an IC50 of 6.66 mg/L. Transketolase-IN-7 is a transketolase (TK) inhibitor that interacts with the TK enzyme by forming hydrogen bonds. Transketolase-IN-7 can be used for research of plant herbicides.
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