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Cat. No.: HY-128776

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Antitumor agent-19

Antitumor agent-19 is an antitumor agent that targets tumor-associated macrophages (TAMs) and can be used as a potent TAMs modulator. Antitumor agent-19 can increase TNF-alpha levels in tumor cells with EC₅₀ values???of 17.18 μM and 18.87 μM in RAW 264.7 cells and BMDM cells, respectively.

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CAS No.: 2379727-90-7
Formule: C₂₄H₂₁ClF₃N₅O
Masse moléculaire:487.90

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Antitumor agent-19 Chemical Structure

CAS No.: 2379727-90-7

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Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

IC₅₀ & Target

tumor-associated macrophages (TAMs)^[1]

Voir tous les produits spécifiques à Isoform TNF Receptor :

Cellular Effect

Cell Line	Type	Value	Description	References
BMDM	EC₅₀	18.87 μM Compound: 23a	Increase in TNF-alpha production in mouse BMDM cells incubated for 24 hrs by ELISA Increase in TNF-alpha production in mouse BMDM cells incubated for 24 hrs by ELISA	[PMID: 31605873]
RAW264.7	EC₅₀	17.18 μM Compound: 23a	Increase in TNF-alpha production in mouse RAW264.7 cells incubated for 24 hrs by ELISA Increase in TNF-alpha production in mouse RAW264.7 cells incubated for 24 hrs by ELISA	[PMID: 31605873]

In Vitro

Antitumor agent-19 (Compound 23a; 10-50 μM; 1 hour; RAW 264.7 cells) treatment effectively induces the expression of M1-phenotype macrophage markers (IL-1β, TNF-α, iNOS and IL-12α) in a dose-dependent manner. Antitumor agent-19 is found to dose-dependently repolarize TAMs from M1 (anti-tumor) and M2 (pro-tumor)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR^[1]

Cell Line:

RAW 264.7 cells
Concentration:

10 µM, 20 µM, or 50 µM
Incubation Time:

1 hour
Result:

Induced the expression of M1-phenotype macrophage markers (IL-1β, TNF-α, iNOS and IL-12α) in a dose-dependent manner.

In Vivo

Antitumor agent-19 (Compound 23a; 5 mg/kg; intraperitoneal injection; every other day; for 30 days; C57BL/6 female mice) is capable of remarkably inhibiting tumor growth of the LLC mouse model. Moreover, the synergy of Antitumor agent-19 with anti-PD-1 antibody has more superior antineoplastic effects than the exclusive use of either in vivo^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Six-to eight-week-old C57BL/6 female mice with lewis lung cancer cells (LLC)^[1]
Dosage:

5 mg/kg
Administration:

Intraperitoneal injection; every other day; for 30 days
Result:

Remarkably inhibited tumor growth of the LLC mouse model.

Chemical Information

CAS No. 2379727-90-7
Masse moléculaire 487.90
Formule C₂₄H₂₁ClF₃N₅O
SMILES

O=C(NC1CCC(NC2=C3C(C4=CN(C)N=C4)=CC=C2)=C3C1)NC5=CC=C(Cl)C(C(F)(F)F)=C5
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Pei H, et al. iscovery of potent ureido tetrahydrocarbazole derivatives for cancer treatments through targeting tumor-associated macrophages. Eur J Med Chem. 2019 Sep 28;183:111741. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
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- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références

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Antitumor agent-19

Voir tous les produits spécifiques à Isoform TNF Receptor

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Antitumor agent-19 Related Classifications

HY-128776 Related Classifications