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Cat. No.: HY-184113

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Dihydropelitinib

(Synonyms: DHP)

Dihydropelitinib (DHP) is a ILK ligand with a K_d value of 252 nM. Dihydropelitinib acts as a cytoskeleton modulator that induces actin (Actin) cytoskeleton rearrangement. Dihydropelitinib exhibits anticancer activity against liver cancer and lung adenocarcinoma. Dihydropelitinib can be used in studies related to liver cancer and lung adenocarcinoma.

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Formule: C₂₄H₂₅ClFN₅O₂
Masse moléculaire:469.94

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Dihydropelitinib Chemical Structure

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
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Description

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In Vitro

Dihydropelitinib (0.019-2.500 μM) binds specifically to the ILK:α-parvin complex, with an equilibrium dissociation constant (K_d) of 252 nM^[1].
Dihydropelitinib (serial dilution; 2 h treatment) binds to full-length ILK in digitonin (HY-N4000)-permeabilized HEK293T cells, with an IC₅₀ of 980 nM as determined by NanoBRET target binding assay^[1].
Dihydropelitinib (0.22-2.50 μM; 48 h) induces concentration-dependent rearrangement of the actin cytoskeleton in hepatocellular carcinoma Huh-7 cells after 48 h of treatment^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Masse moléculaire 469.94
Formule C₂₄H₂₅ClFN₅O₂
SMILES

FC(C=CC(NC1=C(C=NC2=CC(OCC)=C(NC(CCCN(C)C)=O)C=C12)C#N)=C3)=C3Cl
Synonyms

DHP
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Greco FA, et al. Identification and Validation of 3-Cyano-Quinoline Ligands Targeting Integrin-Linked Kinase (ILK). J Med Chem. 2026 Jun 11;69(11):12982-13001. [Content Brief]

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1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Dihydropelitinib

Voir tous les produits spécifiques à Isoform Integrin

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Dihydropelitinib Related Classifications

HY-184113 Related Classifications