Heptenophos
Heptenophos is an inhibitor of AChE and plasma carboxylesterase (CES). By inhibiting AChE activity, Heptenophos causes the accumulation of acetylcholine at cholinergic synapses, thereby triggering typical symptoms of organophosphate poisoning. Heptenophos exhibits rapid lethal toxicity in male albino mice, but its toxic effects are effectively antagonized by obidoxime, and Memantine (HY-B0591) further enhances the detoxification efficacy of obidoxime. Therefore, Heptenophos is commonly used in studies related to the mechanism of organophosphate poisoning and detoxification strategies.
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- CAS No.: 23560-59-0
- Formule: C9H12ClO4P
- Masse moléculaire:250.61
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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AChE |
The intravenous LD50 of Heptenophos in male albino mice is 196.68 μmol/kg. When administered in combination, obidoxime chloride (HY-W011108) at an ED50 of 21.56 μmol/kg is required to achieve a 50% survival rate (Heptenophos at 1.3 LD50; intravenous injection; single administration)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:albino mice (male, 18-24 g)[1]
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Dosage:1.3 LD50; 196.68 μmol/kg (LD50)
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Administration:i.v.; single dose
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Result:Induced severe inhibition of central, peripheral, and erythrocyte AChE as well as plasma carboxylesterase, leaving 3.33% of erythrocyte AChE, 3.37% of brain AChE, 13.05% of diaphragmal AChE, and 7.3% of plasma carboxylesterase activity uninhibited.
Reached an intravenous LD50 of 196.68 μmol/kg (95% confidence interval: 163.72-208.41).
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Animal Model:Albino mice (male, 18-24 g)[2]
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Dosage:1.3 LD50 (toxic challenge); 196.68 μmol/kg (LD50 determination)
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Administration:i.v.; single dose
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Result:Determined an intravenous LD50 of 196.68 μmol/kg (95% confidence interval: 163.72-208.41 μmol/kg).
Required an obidoxime ED50 of 21.56 μmol/kg to achieve 50% survival when administered concurrently with 1.3 LD50 heptenophos.
Chemical Information
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CAS No. 23560-59-0
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Masse moléculaire 250.61
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Formule C9H12ClO4P
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SMILES
O=P(OC1=C(Cl)C2C=CCC12)(OC)OC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Heptenophos Related Classifications
HY-120042 Related Classifications
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