LSD1-IN-47
LSD1-IN-47 is a highly efficient PROTAC degrader targeting LSD1 (IC50 = 43 nM). LSD1-IN-47 does not alter LSD1 protein levels and does not increase the histone marker H3K4me2. LSD1-IN-47 can be used for the study of colon carcinoma.
(Pink: LSD1 ligand (HY-17447A); Blue: VHL ligand (HY-125845); Black: linker).
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- Formule: C44H62N6O5S
- Masse moléculaire:787.07
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Activité biologique
LSD1-IN-47 (Compound 52) (0.2-20 μM, 24-72 h) does not significantly alter LSD1 protein levels in HCT116 (human colon carcinoma cells) cells, and does not increase the histone marker H3K4me2[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCT116 cells
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Concentration:0.2 μM, 2 μM, 20 μM
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Incubation Time:24 h, 48 h, 72 h
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Result:Did not induce LSD1 degradation or affect H3K4me2 levels.
Chemical Information
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Masse moléculaire 787.07
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Formule C44H62N6O5S
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SMILES
CC1=C(SC=N1)C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(CCCCCCCCCCCNC(C4=CC=C([C@H]5[C@H](N)C5)C=C4)=O)=O)=O)O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LSD1-IN-47 Related Classifications
HY-179229 Related Classifications
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