Resveratroloside
Based on 2 publication(s) in Google Scholar
Resveratroloside (Resveratrol glycoside) is an orally active competitive inhibitor of α-glucosidase. Resveratroloside has hypoglycemic and cardioprotective effects. Resveratroloside can be used for the research of diabetes and heart system diseases.
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- Pureté: 99.88%
- CAS No.: 38963-95-0
- Formule: C20H22O8
- Masse moléculaire:390.38
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Stockage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Publications Citing Use of MedChemExpress (MCE) Resveratroloside
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Activité biologique
Resveratroloside (10 mg/kg; intraperitoneal injection; single dose) exerts improvement effects in rat models of myocardial ischemia-reperfusion[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Kunming mice (18-22 g) were induced with diabetes by Alloxan (HY-W017227)[1]
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Dosage:10, 30 and 50 mg/kg
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Administration:Oral administration; single dose
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Result:Significantly reduced postprandial blood glucose levels in a dose-dependent manner in both normal and diabetic mice after starch loading, and its hypoglycemic effect was stronger than that of Resveratrol (HY-16561) at the same dose of 30 mg/kg.
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Animal Model:Male Wistar rats (339.5±9.8 g) with myocardial ischemia-reperfusion model induced by 30-min occlusion of the left coronary artery followed by 120-min reperfusion[2]
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Dosage:10 mg/kg
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Administration:Intraperitoneal injection; single dose
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Result:Had a cardioprotective effect, the myocardial infarct area was reduced to 41.6±4.8% of the risk area, showing a statistically significant decrease compared to the control group (55.0±4.0%).
Chemical Information
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CAS No. 38963-95-0
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Appearance Solid
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Masse moléculaire 390.38
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Formule C20H22O8
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Color White to off-white
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SMILES
OC1=CC(O)=CC(/C=C/C(C=C2)=CC=C2O[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)CO)=C1
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Synonyms
Resveratrol glycoside; trans-Resveratrol 4'-O-β-D-glucopyranoside
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (2)
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Journal Impact Factor
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Most Recent
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Behav Brain Res
Resveratrol glycoside mediates microglial endoplasmic reticulum stress to mitigate LPS-induced sepsis-associated cognitive dysfunction. [Abstract]2023 Apr 12:443:114326. PMID: 36812790
Resveratroloside purchased from MedChemExpress. Usage Cited in: Behav Brain Res. 2023 Apr 12:443:114326. [Abstract]
Resveratroloside (resveratrol glycoside; RG; 250 mg/kg; i.p.; single daily for 7 days) alleviates the abnormal high expression of ERS-related protein PERK/CHOP in the whole brain induced by LPS in mice.
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Clin Exp Nephrol
Resveratrol glycoside inhibits NLRP3/IL-1β/NF-κB to alleviate peritoneal fibrosis in peritoneal dialysis. [Abstract]2025 Jun 17. PMID: 40526291
Solvant et solubilité
DMSO : 200 mg/mL (512.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (6.40 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (6.40 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
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Fiche technique (274 KB)
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SDS (393 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Zhao X, et al. Resveratroloside Alleviates Postprandial Hyperglycemia in Diabetic Mice by Competitively Inhibiting α-Glucosidase. J Agric Food Chem. 2019 Mar 13;67(10):2886-2893. [Content Brief]
[2]. Naumenko SE, et al. Cardioprotective effect of resveratrol and resveratroloside. Cardiovasc Hematol Agents Med Chem. 2013 Sep;11(3):207-10. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5616 mL | 12.8080 mL | 25.6161 mL | 64.0402 mL |
| 5 mM | 0.5123 mL | 2.5616 mL | 5.1232 mL | 12.8080 mL | |
| 10 mM | 0.2562 mL | 1.2808 mL | 2.5616 mL | 6.4040 mL | |
| 15 mM | 0.1708 mL | 0.8539 mL | 1.7077 mL | 4.2693 mL | |
| 20 mM | 0.1281 mL | 0.6404 mL | 1.2808 mL | 3.2020 mL | |
| 25 mM | 0.1025 mL | 0.5123 mL | 1.0246 mL | 2.5616 mL | |
| 30 mM | 0.0854 mL | 0.4269 mL | 0.8539 mL | 2.1347 mL | |
| 40 mM | 0.0640 mL | 0.3202 mL | 0.6404 mL | 1.6010 mL | |
| 50 mM | 0.0512 mL | 0.2562 mL | 0.5123 mL | 1.2808 mL | |
| 60 mM | 0.0427 mL | 0.2135 mL | 0.4269 mL | 1.0673 mL | |
| 80 mM | 0.0320 mL | 0.1601 mL | 0.3202 mL | 0.8005 mL | |
| 100 mM | 0.0256 mL | 0.1281 mL | 0.2562 mL | 0.6404 mL |
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