Salbutamol adipate
Based on 6 publication(s) in Google Scholar
Salbutamol (Albuterol) adipate is an orally active short-acting β2-adrenergic receptor agonist. Salbutamol adipate promotes tumorigenesis in gastric cancer cells through the β2-AR/ERK/EMT pathway. Salbutamol adipate can relax bronchial smooth muscle and is used to study bronchospasm induced by asthma and chronic obstructive pulmonary disease.
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- CAS No.: 149234-08-2
- Formule: C13H21NO3.1/2C6H10O4
- Masse moléculaire:312.38
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Activité biologique
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β adrenergic receptor |
Salbutamol (16 μM; 24 h) adipate significantly induces EMT, migration and invasion by ERK (extracellular signal-regulated kinase) phosphorylation in gastric cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MGC803, SGC7901
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Concentration:16 μM
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Incubation Time:24 h
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Result:Increased β2-AR and ERK levels.
Upregulated mesenchymal markers, CDH2 (N-cadherin) and Snail expression, and decreased the expression of epithelial marker CDH1 (E-cadherin).
Salbutamol (6 mg/kg; oral administration; 4 weeks) adipate has a significant protective effect against Streptozotocin (HY-13753)-induced skeletal muscle atrophy in diabetic rats[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Streptozotocin induced diabetic rats[2]
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Dosage:6 mg/kg
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Administration:Oral administration (p.o.); 4 weeks
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Result:Enhanced muscle grip strength, coordination, and antioxidant levels.
Reduced proinflammatory markers and oxidative stress.
Reduced serum muscle biomarkers.
Increased testosterone, restored lipidemic levels, and improved muscle cellular architecture.
Chemical Information
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CAS No. 149234-08-2
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Masse moléculaire 312.38
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Formule C13H21NO3.1/2C6H10O4
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SMILES
O=C(CCCCC(O)=O)O.OC1=CC=C(C(CNC(C)(C)C)O)C=C1CO.[1/2]
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Synonyms
Albuterol adipate; AH-3365 adipate
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (6)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
Sleep Deprivation Triggers the Excessive Activation of Ovarian Primordial Follicles via β2 Adrenergic Receptor Signaling. [Abstract]2024 Nov;11(41):e2402393. PMID: 39229959
Salbutamol adipate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Nov;11(41):e2402393. [Abstract]
Salbutamol (SAL) (0.2 mg/kg; i.p.; 6 d) significantly decreased both ovarian weight and the number of primordial follicles in C57BL/6J mice, along with a declining trend in the total follicle count.
Salbutamol adipate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Nov;11(41):e2402393. [Abstract]
Salbutamol (SAL) (0.2 mg/kg; i.p.; 6 d) led to the upregulation of ADRB2 receptor expression in the granulosa cells of ovarian tissue in C57BL/6J mice.
Salbutamol adipate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Nov;11(41):e2402393. [Abstract]
Salbutamol (SAL) (0.2 mg/kg; i.p.; 6 d) significantly increased the protein expression levels of KIT and KITL in the ovarian tissue in C57BL/6J mice.
Salbutamol adipate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Nov;11(41):e2402393. [Abstract]
Salbutamol (SAL) (100 µM; 24 h) considerably increased the mRNA expression level of KITL in the ovarian granulosa cell line KGN.
Salbutamol adipate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Nov;11(41):e2402393. [Abstract]
Salbutamol (SAL) (100 µM; 24 h) increased the cAMP concentration in KGN cells.
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Chin Med J (Engl)
Skin-localized sympathetic nerve-keratinocyte crosstalk fuels psoriatic inflammation via neutrophil recruitment. [Abstract]2026 Apr 23. PMID: 42036893 -
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Anal Chem
2025 Jul 15;97(27):14220-14229. PMID: 40601392 -
Respir Res
Nebulization of risedronate alleviates airway obstruction and inflammation of chronic obstructive pulmonary diseases via suppressing prenylation-dependent RAS/ERK/NF-κB and RhoA/ROCK1/MLCP signaling. [Abstract]2022 Dec 28;23(1):380. PMID: 36575527 -
Mol Biol Rep
Cardiac drug potential: exploring individual and combined cardiac drugs to promote differentiation of adipose-derived stem cells into cardiomyocytes. [Abstract]2026 Feb 26;53(1):434. PMID: 41746444
Pureté et documentation
Références
[1]. Lu Y, et al. Chronic stress model simulated by salbutamol promotes tumorigenesis of gastric cancer cells through β2-AR/ERK/EMT pathway. J Cancer. 2022 Jan 1;13(2):401-412. [Content Brief]
[2]. Hong YP, et al. Effects of Castanospermine on Inflammatory Response in a Rat Model of Experimental Severe Acute Pancreatitis. Arch Med Res. 2016 Aug;47(6):436-445. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Salbutamol adipate Related Classifications
HY-B1037B Related Classifications
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