SMU-CX1
Based on 1 Customer Validation
SMU-CX1 is a specific TLR3 inhibitor (IC50: 0.11 μM) with IC50 ranging from 0.14-0.33 μM against multiple influenza A virus subtypes. SMU-CX1 inhibits the viral PB2 and NP proteins with an IC50 of 0.43 μM for SARS-CoV-2 activity. SMU-CX1 also inhibits inflammatory factors in host cells, including IFN-β, IP-10, and CCL-5.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 99.9%
- CAS No.: 10371-86-5
- Formule: C18H16N2O
- Masse moléculaire:276.33
-
Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | CC50 |
5.33 μM
Compound: NSC69187; SMU-CX
|
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 38387691] |
| BEAS-2B | CC50 |
5.33 μM
Compound: NSC69187; SMU-CX
|
Cytotoxicity against human BEAS-2B cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human BEAS-2B cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 38387691] |
| HEK-293T | CC50 |
5.33 μM
Compound: NSC69187; SMU-CX
|
Cytotoxicity against human HEK293T cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human HEK293T cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 38387691] |
| KB | ED50 |
8.7 μg/mL
Compound: 9-methoxy ellipticine
|
Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
|
[PMID: 7130986] |
| MDCK | CC50 |
5.33 μM
Compound: NSC69187; SMU-CX
|
Cytotoxicity against MDCK cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against MDCK cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 38387691] |
| R1 | IC50 |
90 μM
Compound: 4
|
Inhibition of glucocorticoid receptor-glucocorticoid complex transfected in rat R1 cells assessed as down-regulation of TPA-responsive element proinflammatory gene expression after 24 hrs by beta-galactosidase assay
Inhibition of glucocorticoid receptor-glucocorticoid complex transfected in rat R1 cells assessed as down-regulation of TPA-responsive element proinflammatory gene expression after 24 hrs by beta-galactosidase assay
|
[PMID: 18412397] |
| Vero C1008 | CC50 |
>10 μM
Compound: NSC69187; SMU-CX
|
Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability by CCK-8 assay
Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability by CCK-8 assay
|
[PMID: 38387691] |
Chemical Information
-
CAS No. 10371-86-5
-
Appearance Solid
-
Masse moléculaire 276.33
-
Formule C18H16N2O
-
Color Light yellow to yellow
-
SMILES
COC1=CC=C2C(C(C(C)=C3C(C=CN=C3)=C4C)=C4N2)=C1
-
Structure Classification
-
Initial Source
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Pureté et documentation
-
Fiche technique (270 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SMU-CX1 Related Classifications
HY-N12110 Related Classifications
Powered by Bioz