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Cat. No.: HY-10082B

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Triapine hydrochloride

(Synonyms: 3-AP hydrochloride; PAN-811 hydrochloride; OCX191 hydrochloride)

11 Cited Publications

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Based on 11 publication(s) in Google Scholar

Triapine (hydrochloride) is the hydrochloride form of Triapine (HY-10082). Triapine (3-AP; PAN-811) is a potent inhibitor of the M2 subunit of ribonucleotide reductase (RR), and is a potent radiosensitizer.

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CAS No.: 216240-62-9
Formule: C₇H₁₀ClN₅S
Masse moléculaire:231.71

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Triapine hydrochloride Chemical Structure

CAS No.: 216240-62-9

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Description

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Chemical Information

CAS No. 216240-62-9
Masse moléculaire 231.71
Formule C₇H₁₀ClN₅S
SMILES

S=C(N)N/N=C/C1=NC=CC=C1N.[H]Cl
Synonyms

3-AP hydrochloride; PAN-811 hydrochloride; OCX191 hydrochloride
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (11)

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Journal Impact Factor

Nature

Lithocholic acid phenocopies anti-ageing effects of calorie restriction. [Abstract]

2025 Jul;643(8070):192-200. PMID: 39695227
Cell Death Dis

RRM1 inhibition sensitizes lung adenocarcinoma to decitabine treatment. [Abstract]

2026 Feb 26;17(1):275. PMID: 41748545
Cancer Lett

Inhibition of Ribonucleotide Reductase Subunit M2 Enhances the Radiosensitivity of Metastatic Pancreatic Neuroendocrine Tumor. [Abstract]

2024 Aug 1:596:216993. PMID: 38801884
JACS Au

DefNEtTrp: An Iron Dual Chelator Approach for Anticancer Application. [Abstract]

2024 Dec 4;4(12):4799-4808. PMID: 39735911
mBio

Blockade of de novo dNTP biosynthesis pathway delays HIV-1 early life cycle kinetics and dynamics. [Abstract]

2025 Aug 13;16(8):e0104725. PMID: 40586616
J Mol Med (Berl)

Combination of PARP inhibitor and temozolomide to suppress chordoma progression. [Abstract]

2019 Aug;97(8):1183-1193. PMID: 31201471
J Cancer Res Clin Oncol

Synergistic anticancer activity of combined ATR and ribonucleotide reductase inhibition in Ewing's sarcoma cells. [Abstract]

2023 Sep;149(11):8605-8617. PMID: 37097390
Res Sq

2026 Jun 17.
Rush University

2025.
Res Sq

2025 Mar 26.
Research Square Preprint

2023 Jun 9.

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Martin LK, et al. A dose escalation and pharmacodynamic study of Triapine and radiation in patients with locally advanced pancreas cancer. Int J Radiat Oncol Biol Phys. 2012 Nov 15;84(4):e475-81. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Triapine hydrochloride

11 Cited Publications

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Triapine hydrochloride

Publications Citing Use of MedChemExpress (MCE) Triapine hydrochloride

Voir tous les produits spécifiques à Isoform DNA/RNA Synthesis

Activité biologique

Chemical Information

Publications (11)

Pureté et documentation

Références

Calculators

Help & FAQs

Triapine hydrochloride Related Classifications

HY-10082B Related Classifications