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Cat. No.: HY-158692

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Tyk2-IN-18

Tyk2-IN-18 (compound 86) is a potent tyrosine kinase 2 (Tyk2) inhibitor. Tyk2-IN-18 inhibits JAK2-JH2, with an IC₅₀ of ＜10 nM.

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CAS No.: 3024860-29-2
Formule: C₂₁H₂₄F₂N₄O₃
Masse moléculaire:418.44

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Tyk2-IN-18 Chemical Structure

CAS No.: 3024860-29-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

Tyk2-IN-18 (compound 86) is a potent tyrosine kinase 2 (Tyk2) inhibitor. Tyk2-IN-18 inhibits JAK2-JH2, with an IC₅₀ of ＜10 nM^[1]^[2].

IC₅₀ & Target

Tyk2 JH2

<10 nM (IC₅₀)

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Chemical Information

CAS No. 3024860-29-2
Masse moléculaire 418.44
Formule C₂₁H₂₄F₂N₄O₃
SMILES

COCCOC1=CC(C(F)(F)C)=NC(N2CC3(C4=C2C=C(N=C4)NC(C)=O)CC3)=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Ram W. Sabnis. Novel Tyrosine Kinase 2 Inhibitors for Treating Autoimmune and Inflammatory Diseases. ACS Med. Chem. Lett. May 16, 2024.

[2]. Jeffrey Vessels, et al. Tyrosine kinase 2 inhibitors and uses thereof. WO2023250064A1. 2023-12-28.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références

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Tyk2-IN-18

Voir tous les produits spécifiques à Isoform JAK

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Tyk2-IN-18 Related Classifications

HY-158692 Related Classifications