WAY-196025
WAY-196025 is a selective and orally active indole cytosolic phospholipase A2 alpha (cPLA2α) inhibitor with an IC50 of 0.01μM and a Kd of 0.013 μM. WAY-196025 can inhibit the production of prostaglandins (such as PGE2) and leukotrienes (such as LTB4), and reduce the release of inflammatory mediators. WAY-196025 can be used for the researches of inflammation and immunology, such as asthma.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 540523-42-0
- Formule: C42H41ClN2O4S
- Masse moléculaire:705.30
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Voir tous les produits spécifiques à Isoform Phospholipase
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Activité biologique
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cPLA2α 0.01 μM (IC50) |
cPLA2α 0.013 μM (Kd) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MC9 | IC50 |
>1 μM
Compound: 121
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Inhibition of PGF2apha production in arachidonic acid-stimulated mouse MC9 cells
Inhibition of PGF2apha production in arachidonic acid-stimulated mouse MC9 cells
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[PMID: 18498150] |
| MC9 | IC50 |
0.006 μM
Compound: 121
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Inhibition of PGF2alpha production in mouse MC9 cells
Inhibition of PGF2alpha production in mouse MC9 cells
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[PMID: 18498150] |
| MC9 | IC50 |
0.012 μM
Compound: 121
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Inhibition of LTB4 production in mouse MC9 cells
Inhibition of LTB4 production in mouse MC9 cells
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[PMID: 18498150] |
Chemical Information
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CAS No. 540523-42-0
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Masse moléculaire 705.30
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Formule C42H41ClN2O4S
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SMILES
O=C(O)C1=CC=C(CCCC2=C(CCNS(=O)(CC3=C(C)C=CC=C3C)=O)N(C(C4=CC=CC=C4)C5=CC=CC=C5)C6=C2C=C(Cl)C=C6)C=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. McKew JC, et al. Indole cytosolic phospholipase A2 alpha inhibitors: discovery and in vitro and in vivo characterization of 4-{3-[5-chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoic acid, efipladib. J Med Chem. 2008 Jun 26;51(12):3388-413. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
WAY-196025 Related Classifications
HY-119094 Related Classifications
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