540523-42-0
Chemical Structure
WAY-196025
- CAS No.: 540523-42-0
- Formula:C42H41ClN2O4S
- Molecular Weight:705.30
IUPAC Name: 4-(3-(1-benzhydryl-5-chloro-2-(2-(((2,6-dimethylphenyl)methyl)sulfonamido)ethyl)-1H-indol-3-yl)propyl)benzoic acid
InChIKey: YOFBEFNLUYVWRR-UHFFFAOYSA-N
SMILES: O=C(O)C1=CC=C(CCCC2=C(CCNS(=O)(CC3=C(C)C=CC=C3C)=O)N(C(C4=CC=CC=C4)C5=CC=CC=C5)C6=C2C=C(Cl)C=C6)C=C1
Biological Activity: WAY-196025 is a selective and orally active indole cytosolic phospholipase A2 alpha (cPLA2α) inhibitor with an IC50 of 0.01μM and a Kd of 0.013 μM. WAY-196025 can inhibit the production of prostaglandins (such as PGE2) and leukotrienes (such as LTB4), and reduce the release of inflammatory mediators. WAY-196025 can be used for the researches of inflammation and immunology, such as asthma[1].
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WAY-196025 | WAY-196025 is a selective and orally active indole cytosolic phospholipase A2 alpha (cPLA2α) inhibitor with an IC50 of 0.01μM and a Kd of 0.013 μM. WAY-196025 can inhibit the production of prostaglandins (such as PGE2) and leukotrienes (such as LTB4), and reduce the release of inflammatory mediators. WAY-196025 can be used for the researches of inflammation and immunology, such as asthma. | |||||||||||||||||||||
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- [1]. McKew JC, et al. Indole cytosolic phospholipase A2 alpha inhibitors: discovery and in vitro and in vivo characterization of 4-{3-[5-chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoic acid, efipladib. J Med Chem. 2008 Jun 26;51(12):3388-413. [Content Brief]
Keywords
