Hapalindole Q
Hapalindole Q (Compound (+)-1) is an autophagy (Autophagy) inhibitor targeting YAP1. Hapalindole Q binds to the Hippo pathway transcription factor YAP1 with a Kd of 9.13 μM and induces its degradation via the chaperone-mediated autophagy (CMA) pathway. This process inhibits Rab7-mediated fusion of autophagosomes and lysosomes, thereby reducing overall autophagy levels without affecting lysosomal function. Hapalindole Q holds promise for research in cancer (e.g., liver cancer, breast cancer, etc.).
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- CAS No.: 106928-29-4
- Formule: C21H24N2S
- Masse moléculaire:336.49
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Activité biologique
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Chemical Information
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Activité biologique
Chemical Information
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CAS No. 106928-29-4
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Masse moléculaire 336.49
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Formule C21H24N2S
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SMILES
C[C@](CC[C@H]([C@@H]1C2=CNC3=CC=CC=C32)C(C)=C)([C@@H]1N=C=S)C=C
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Structure Classification
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Initial Source
Hapalosiphon fontinalis
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Hapalindole Q Related Classifications
HY-173150 Related Classifications
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