74817-61-1
Chemical Structure
Murabutide
- CAS No.: 74817-61-1
- Formula:C23H40N4O11
- Molecular Weight:548.58
IUPAC Name: butyl ((R)-2-(((2R,3R,4R,5R)-2-acetamido-4,5,6-trihydroxy-1-oxohexan-3-yl)oxy)propanoyl)-L-alanyl-D-glutaminate
InChIKey: ISYJGPYKJNWIQE-BNOMVYTKSA-N
SMILES: CC(N[C@@H](C=O)[C@H]([C@H](O)[C@H](O)CO)O[C@H](C)C(N[C@@H](C)C(N[C@H](CCC(N)=O)C(OCCCC)=O)=O)=O)=O
Biological Activity: Murabutide is an immunomodulator and also a NOD2 receptor agonist. Murabutide enhances the signal transduction of ATR and NOD2, mediates the activation of the DDR pathway, and thereby repairs radiation-induced DNA double-strand breaks. Murabutide inhibits radiation-induced cell apoptosis and protects cells and mice from radiation-induced toxic damage. Murabutide induces the expression and DNA-binding activity of Oct-1 in macrophages, thereby inhibiting the transcription and replication of HIV-1. Murabutide reduces the expression levels of CD4 and CCR5 on the surface of macrophages, and induces the secretion of β-chemokines, TNF-α and IL-6. Murabutide enhances non-specific viral resistance and targets reticuloendothelial cells. Murabutide can be used in research related to radiation-induced damage and human immunodeficiency virus type 1 infection[1][2][3].
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Murabutide | Murabutide is an immunomodulator and also a NOD2 receptor agonist. Murabutide enhances the signal transduction of ATR and NOD2, mediates the activation of the DDR pathway, and thereby repairs radiation-induced DNA double-strand breaks. Murabutide inhibits radiation-induced cell apoptosis and protects cells and mice from radiation-induced toxic damage. Murabutide induces the expression and DNA-binding activity of Oct-1 in macrophages, thereby inhibiting the transcription and replication of HIV-1. Murabutide reduces the expression levels of CD4 and CCR5 on the surface of macrophages, and induces the secretion of β-chemokines, TNF-α and IL-6. Murabutide enhances non-specific viral resistance and targets reticuloendothelial cells. Murabutide can be used in research related to radiation-induced damage and human immunodeficiency virus type 1 infection. | |||||||||||||||||||||
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References
- [1]. Liu L, et al. NOD2 agonist murabutide alleviates radiation-induced injury through DNA damage response pathway mediated by ATR. Journal of cellular physiology. 2019 Nov;234(11):21294-21306. [Content Brief]
- [2]. Truong MJ, et al. Differentially expressed genes in HIV-1-infected macrophages following treatment with the virus-suppressive immunomodulator murabutide. Virus research. 2004 Jan;99(1):25-33. [Content Brief]
- [3]. Darcissac EC, et al. The synthetic immunomodulator murabutide controls human immunodeficiency virus type 1 replication at multiple levels in macrophages and dendritic cells. Journal of virology. 2000 Sep;74(17):7794-802. [Content Brief]
