1. GPCR/G Protein
    Neuronal Signaling
  2. Cannabinoid Receptor
  3. CB1 inverse agonist 1

CB1 inverse agonist 1 

Cat. No.: HY-135280
Handling Instructions

CB1 inverse agonist 1 is a highly potent, orally active, and specific inverse agonist of CB1 receptor with IC50s of 7.5 nM and 4100 nM for CB1 and CB2 receptors, respectively. Anorexigenic effects.

For research use only. We do not sell to patients.

CB1 inverse agonist 1 Chemical Structure

CB1 inverse agonist 1 Chemical Structure

CAS No. : 852315-00-5

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

CB1 inverse agonist 1 is a highly potent, orally active, and specific inverse agonist of CB1 receptor with IC50s of 7.5 nM and 4100 nM for CB1 and CB2 receptors, respectively. Anorexigenic effects[1].

IC50 & Target

CB1

7.5 nM (IC50)

CB2

4100 nM (IC50)

In Vivo

CB1 inverse agonist 1 (Compound 14; 0.3, 1, or 3 mg/kg)inhibits feeding in a dose-dependent manner[1].
The pharmacokinetic profile of CB1 inverse agonist 1 is evaluated in Sprague-Dawley rats, C57BL/6 mice, beagles, and rhesus macaques with t1/2 of >8, >8, >24, and 22 h, respectively[1].

Animal Model: Rat[1]
Dosage: 0.3, 1, or 3 mg/kg
Administration: PO
Result: Inhibited feeding in a dose-dependent manner. 3 mg/kg decreased cumulative food intake from 2 h post-dosing. Decreased overnight body weight gain compared to vehicle treatment at all dosing levels.
Molecular Weight

514.79

Formula

C₂₅H₁₈Cl₃N₃O₃

CAS No.

852315-00-5

SMILES

CC(NC1=C(C(C)=O)C(N(C)C2=NC(C3=CC=C(Cl)C=C3Cl)=C(C4=CC=C(Cl)C=C4)C=C12)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

CB1 inverse agonist 1Cannabinoid ReceptorCannabinoidCB1InverseagonistAnorexigenicObesityInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product name:
CB1 inverse agonist 1
Cat. No.:
HY-135280
Quantity:
MCE Japan Authorized Agent: