Anti-inflammatory agent 41
Anti-inflammatory agent 41 (13a) significantly inhibit lipopolysaccharide (LPS)-induced expression of the proinflammatory cytokines IL-6 and TNF-α on J774A.1, THP-1 and LX-2 cells, and inhibits the activation of the NF-κB pathway.
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- CAS. Nr.: 2896204-90-1
- Formel: C33H25N3O5
- Molecular Weight:543.57
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| J774.A1 | IC50 |
1.332 μM
Compound: 13a
|
Antiinflammatory activity in LPS-induced mouse J774.A1 cells assessed as inhibition of LPS-induced IL-6 release preincubated for 30 mins followed by LPS stimulation for 24 hrs by ELISA method
Antiinflammatory activity in LPS-induced mouse J774.A1 cells assessed as inhibition of LPS-induced IL-6 release preincubated for 30 mins followed by LPS stimulation for 24 hrs by ELISA method
|
[PMID: 36708679] |
| J774.A1 | IC50 |
2.403 μM
Compound: 13a
|
Antiinflammatory activity in LPS-induced mouse J774.A1 cells assessed as inhibition of LPS-induced TNF-alpha release preincubated for 30 mins followed by LPS stimulation for 24 hrs by ELISA method
Antiinflammatory activity in LPS-induced mouse J774.A1 cells assessed as inhibition of LPS-induced TNF-alpha release preincubated for 30 mins followed by LPS stimulation for 24 hrs by ELISA method
|
[PMID: 36708679] |
| LX-2 | IC50 |
2.625 μM
Compound: 13a
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Antiinflammatory activity in LPS-induced human LX2 cells assessed as inhibition of LPS-induced IL-6 release preincubated for 30 mins followed by LPS stimulation for 24 hrs by ELISA method
Antiinflammatory activity in LPS-induced human LX2 cells assessed as inhibition of LPS-induced IL-6 release preincubated for 30 mins followed by LPS stimulation for 24 hrs by ELISA method
|
[PMID: 36708679] |
| LX-2 | IC50 |
2.908 μM
Compound: 13a
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Antiinflammatory activity in LPS-induced human LX2 cells assessed as inhibition of LPS-induced TNF-alpha release preincubated for 30 mins followed by LPS stimulation for 24 hrs by ELISA method
Antiinflammatory activity in LPS-induced human LX2 cells assessed as inhibition of LPS-induced TNF-alpha release preincubated for 30 mins followed by LPS stimulation for 24 hrs by ELISA method
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[PMID: 36708679] |
| THP-1 | IC50 |
1.328 μM
Compound: 13a
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Antiinflammatory activity in LPS-induced human THP-1 cells assessed as inhibition of LPS-induced IL-6 release preincubated for 30 mins followed by LPS stimulation for 24 hrs by ELISA method
Antiinflammatory activity in LPS-induced human THP-1 cells assessed as inhibition of LPS-induced IL-6 release preincubated for 30 mins followed by LPS stimulation for 24 hrs by ELISA method
|
[PMID: 36708679] |
| THP-1 | IC50 |
1.667 μM
Compound: 13a
|
Antiinflammatory activity in LPS-induced human THP-1 cells assessed as inhibition of LPS-induced TNF-alpha release preincubated for 30 mins followed by LPS stimulation for 24 hrs by ELISA method
Antiinflammatory activity in LPS-induced human THP-1 cells assessed as inhibition of LPS-induced TNF-alpha release preincubated for 30 mins followed by LPS stimulation for 24 hrs by ELISA method
|
[PMID: 36708679] |
Anti-inflammatory agent 41 (13a) significantly reduced the LPS-induced nuclear translocation of p65 in J774A.1 macrophages[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2896204-90-1
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Molecular Weight 543.57
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Formel C33H25N3O5
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SMILES
COC1=CC2=C(C(OC3=CC=C(C=C3)NC(C4=CN(C5=CC=CC=C5C4=O)C6=CC=CC=C6)=O)=CC=N2)C=C1OC
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
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Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Anti-inflammatory agent 41 Related Classifications
HY-149816 Related Classifications
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