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Art. -Nr.: HY-143273

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DENV-IN-6

DENV-IN-6 is a potent DENV (I-IV) inhibitor with EC₅₀s of 17.5, 13.20, 6.8 and 11.41 μM for the inhibition of DENV (I-IV) replication, respectively. DENV-IN-6 also exhibits activity of anti-HIV-1_IIIB (EC₅₀=0.0181 µM; CC₅₀=64.92 µM).

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CAS. Nr.: 2375780-95-1
Formel: C₂₃H₂₆ClFN₄OS
Molecular Weight:461.00

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

DENV-IN-6 Chemical Structure

CAS. Nr.: 2375780-95-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- In Vitro
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Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

HIV (IIIB)

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In Vitro

DENV-IN-6 (compound 4a) (0.04, 0.2, 1, 5, 25 μM; 5 days) shows inhibitory effect on replication of DENV (I-IV) in a dose-dependent manner (EC₅₀s=17.5, 13.20, 6.8 and 11.41 μM, respectively)^[1].
DENV-IN-6 (25 μM; 5 days) shows low toxic to Vero cells (CC₅₀＞200 μM) and exhibits stronger inhibitory effect on DENV-III than on DENV-I, II, IV with a TI value is greater than 29.41 (Therapeutic index (TI): ratio CC₅₀/IC₅₀)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

Vero cells
Concentration:

0.04, 0.2, 1, 5, 25 μM
Incubation Time:

5 days
Result:

Surpressed replication of DENV (I-IV) in a dose-dependent manner and with EC₅₀s of 17.5, 13.20, 6.8 and 11.41 μM, respectively.

Cell Cytotoxicity Assay^[1]

Cell Line:

Vero cells
Concentration:

25 μM
Incubation Time:

5 days
Result:

Exhibited low toxic to Vero cells with a CC₅₀ value was greater than 200 μM.
Showed stronger inhibitory effect on DENV-III than on DENV-I, II, IV (Therapeutic index (TI) values of DENV (I-IV):＞11.43, ＞15.15, ＞29.41, ＞17.53).

Chemical Information

CAS. Nr. 2375780-95-1
Molecular Weight 461.00
Formel C₂₃H₂₆ClFN₄OS
SMILES

CCC1=C(N=C(NC1=O)SCC2=NNC(C3=CC=C(C=C3)F)=C2Cl)CC4CCCCC4
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Rui RM, et al. C6-structural optimizations of 2-aryl-1H-pyrazole-S-DABOs: From anti-HIV to anti-DENV activity. Bioorg Chem. 2022 Feb;119:105494. [Content Brief]

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Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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DENV-IN-6

Alle HIV Isoform-spezifische Produkte anzeigen

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

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DENV-IN-6 Related Classifications

HY-143273 Related Classifications