Aurka - aurora kinase A Gene

Also Known as Stk6; ARK-1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 261730

About Aurka

Primary_assembly 3: 161,128,313-161,144,390 reverse strand.mRatBN7.2:CM026976.1

This gene has 5 transcripts (splice variants), 236 orthologues, 2 paralogues and is associated with 24 phenotypes. Biased expression in Adrenal (RPKM 261.), Liver (RPKM 143.3) and 9 other tissues.

Summary

Enables protein serine/threonine kinase activity. Involved in protein phosphorylation and response to estradiol. Located in centrosome and spindle. Human ortholog(s) of this gene implicated in colorectal cancer; ovarian cancer; and uterine Cancer. Orthologous to human AURKA (Aurora Kinase A). [provided by Alliance of Genome Resources, Apr 2022]

Aurka Products (1)

mRNA Protein Name
NM_153296.3 NP_695208.2 aurora kinase A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
12124350 RGD
Biological Process GO Annotation Evidence References Source
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
12124350 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
15601761 RGD
Cellular Component GO Annotation Evidence References Source
located in centrosome IDA
IDA: Inferred from direct assay
12124350 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Aurka Protein Structure

STKc_Aurora-A

STKc_Aurora-A: cd14116 (119 - 375)

  • 0
  • 100
  • 200
  • 300
  • 397 a.a.
Protein Preferred Names Protein Names

aurora kinase A

  • aurora 2

  • aurora-A

  • aurora-related kinase 1

  • aurora/IPL1-related kinase 1

  • ipl1- and aurora-related kinase 1

  • ratAurA

  • serine/threonine kinase 6

  • serine/threonine-protein kinase 15

  • serine/threonine-protein kinase 6

  • serine/threonine-protein kinase Ayk1

  • serine/threonine-protein kinase aurora-A

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-11103 Sitaxsentan sodium 98.83% Unkown

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-157396 JAB-2485 99.87% Phase 2
HY-172737 RP-1664 Inhibitor 98.77% Phase 1

Pre-clinical Phase

Bioactive Molecules (42)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-112273 CD532 Inhibitor 98.86% Unkown
HY-103645 GW779439X 99.85% Unkown
HY-125956 Aurkin A 98.0% Unkown
HY-148065 FMF-06-098-1 Inhibitor 98.77% Unkown
HY-171767 SK2188 99.87% Unkown
HY-125911 Gossypin 98.29% Unkown
HY-171768 SK2187 Degrader 95.81% Unkown
HY-168543 PROTAC MPS1 degrader 2 Degrader 99.78% Unkown
HY-112273A CD532 hydrochloride Inhibitor 99.62% Unkown
HY-137344A dAURK-4 hydrochloride Inhibitor 98.14% Unkown
HY-100865 BPR1K871 Inhibitor 99.12% Unkown
HY-175525 MS44 Degrader 99.81% Unkown
HY-181311 CCT400028 98.03% Unkown
HY-168540 PROTAC MPS1 degrader 1 Degrader 99.90% Unkown
HY-180132 PROTAC AURKA degrader 2 Degrader 98.36% Unkown
HY-162469 6K465 Inhibitor 98.61% Unkown
HY-114461B (3S,17S)-FD-895 / Unkown
HY-116190 CFI-401870 Inhibitor / Unkown
HY-125090 PHA-680626 / Unkown
HY-137344 dAURK-4 Inhibitor / Unkown
HY-147703 Aurora kinase inhibitor-9 Inhibitor / Unkown
HY-155464 VEGFR-2/AURKA-IN-1 Chemical / Unkown
HY-158038 AurkA allosteric-IN-1 / Unkown
HY-161407 AURKA-IN-1 Inhibitor / Unkown
HY-162837 AURKA against 1 Inhibitor / Unkown
HY-173499 HLDA-212 / Unkown
HY-175827 MK-5108-NH-PEG2-alkyne Inhibitor / Unkown
HY-175830 PROTAC AURKA degrader 1 Degrader / Unkown
HY-175982 AURKA-IN-3 Inhibitor / Unkown
HY-179375 LCI133 Inhibitor / Unkown
HY-179574 AURKA-IN-4 Inhibitor 99.88% Unkown
HY-179640 SK4454 Degrader / Unkown
HY-179641 SK5527 Degrader / Unkown
HY-181231 PROTAC CDK9 degrader-12 / Unkown
HY-181626 NN-01-195 / Unkown
HY-183098 UNC8209 / Unkown
HY-183100 UNC8461 Control / Unkown
HY-184329 PROTAC AURKB Degrader-1 / Unkown
HY-RS01266 AURKA Human Pre-designed siRNA Set A / Unkown
HY-RS01267 Aurka Mouse Pre-designed siRNA Set A / Unkown
HY-RS01268 Aurka Rat Pre-designed siRNA Set A / Unkown
HY-181568 PROTAC Aurora A Degrader-1 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aurka NCBI NCBI:6790