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Cat. No.: HY-184329

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PROTAC AURKB Degrader-1

PROTAC AURKB Degrader-1 is a selective AURKB PROTAC degrader with a DC₅₀ value of 0.6 nM. PROTAC AURKB Degrader-1 promotes ubiquitination and degradation of AURKB. PROTAC AURKB Degrader-1 downregulates the expression levels of chromosomal passenger complex components Borealin, INCENP, Survivin as well as the transcription factor YY1. PROTAC AURKB Degrader-1 induces G₂/M phase arrest and triggers Apoptosis in cells. PROTAC AURKB Degrader-1 serves as a chemical probe for biological studies of the chromosomal passenger complex. PROTAC AURKB Degrader-1 can be used in research related to acute myeloid leukemia, colorectal cancer, and non-small cell lung cancer.
(Pink: AURKB Target protein ligand; Blue: Cereblon ligand (HY-14658); Black: linker).

For research use only. We do not sell to patients.

CAS No.: 3114874-73-3
Formula: C₄₅H₄₉FN₁₂O₆
Molecular Weight:872.95

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PROTAC AURKB Degrader-1 Chemical Structure

CAS No.: 3114874-73-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

PROTAC AURKB Degrader-1 is a selective AURKB PROTAC degrader with a DC₅₀ value of 0.6 nM. PROTAC AURKB Degrader-1 promotes ubiquitination and degradation of AURKB. PROTAC AURKB Degrader-1 downregulates the expression levels of chromosomal passenger complex components Borealin, INCENP, Survivin as well as the transcription factor YY1. PROTAC AURKB Degrader-1 induces G₂/M phase arrest and triggers Apoptosis in cells. PROTAC AURKB Degrader-1 serves as a chemical probe for biological studies of the chromosomal passenger complex. PROTAC AURKB Degrader-1 can be used in research related to acute myeloid leukemia, colorectal cancer, and non-small cell lung cancer^[1]. (Pink: AURKB Target protein ligand; Blue: Cereblon ligand (HY-14658); Black: linker).

IC₅₀ & Target^[1]

Aurora B

0.6 nM (DC₅₀)

All PROTACs Isoforms :

All Aurora Kinase Isoforms :

In Vitro

PROTAC AURKB Degrader-1 (0-100 nM; 96 h) potently inhibits proliferation across a panel of cancer cell lines, with IC₅₀ values ranging from 3.34 nM in MOLM-13 cells to 342.4 nM in H1299 cells after 96 h treatment, showing greatest potency against AML cell lines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3114874-73-3
Molecular Weight 872.95
Formula C₄₅H₄₉FN₁₂O₆
SMILES

O=C1C(N2C(C(C=C(N3CCN(CCN4CCN(CCCOC5=CC(N=CN=C6NC7=CC(CC(NC8=CC=CC(F)=C8)=O)=NN7)=C6C=C5)CC4)CC3)C=C9)=C9C2=O)=O)CCC(N1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Piao L, et al.. Design, synthesis, and biological evaluation of a potent and selective AURKB degrader. European journal of medicinal chemistry. 2026 Jun 06;316:119040. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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PROTAC AURKB Degrader-1

All PROTACs Isoforms

All Aurora Kinase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PROTAC AURKB Degrader-1 Related Classifications

HY-184329 Related Classifications