2. PROTAC Epigenetics Cell Cycle/DNA Damage Apoptosis
  3. PROTACs Aurora Kinase Survivin Apoptosis
  4. PROTAC AURKB Degrader-1

PROTAC AURKB Degrader-1 is a selective AURKB PROTAC degrader with a DC50 value of 0.6 nM. PROTAC AURKB Degrader-1 promotes ubiquitination and degradation of AURKB. PROTAC AURKB Degrader-1 downregulates the expression levels of chromosomal passenger complex components Borealin, INCENP, Survivin as well as the transcription factor YY1. PROTAC AURKB Degrader-1 induces G2/M phase arrest and triggers Apoptosis in cells. PROTAC AURKB Degrader-1 serves as a chemical probe for biological studies of the chromosomal passenger complex. PROTAC AURKB Degrader-1 can be used in research related to acute myeloid leukemia, colorectal cancer, and non-small cell lung cancer.
(Pink: AURKB Target protein ligand; Blue: Cereblon ligand (HY-14658); Black: linker).

For research use only. We do not sell to patients.

PROTAC AURKB Degrader-1

PROTAC AURKB Degrader-1 Chemical Structure

CAS No. : 3114874-73-3

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PROTAC AURKB Degrader-1 Related Antibodies

Top Publications Citing Use of Products

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Aurora Kinase Aurora A Aurora B Aurora C

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Description

PROTAC AURKB Degrader-1 is a selective AURKB PROTAC degrader with a DC50 value of 0.6 nM. PROTAC AURKB Degrader-1 promotes ubiquitination and degradation of AURKB. PROTAC AURKB Degrader-1 downregulates the expression levels of chromosomal passenger complex components Borealin, INCENP, Survivin as well as the transcription factor YY1. PROTAC AURKB Degrader-1 induces G2/M phase arrest and triggers Apoptosis in cells. PROTAC AURKB Degrader-1 serves as a chemical probe for biological studies of the chromosomal passenger complex. PROTAC AURKB Degrader-1 can be used in research related to acute myeloid leukemia, colorectal cancer, and non-small cell lung cancer[1]. (Pink: AURKB Target protein ligand; Blue: Cereblon ligand (HY-14658); Black: linker).

IC50 & Target[1]

Aurora B

0.6 nM (DC50)

In Vitro

PROTAC AURKB Degrader-1 (0-100 nM; 96 h) potently inhibits proliferation across a panel of cancer cell lines, with IC50 values ranging from 3.34 nM in MOLM-13 cells to 342.4 nM in H1299 cells after 96 h treatment, showing greatest potency against AML cell lines[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PROTAC AURKB Degrader-1 Related Antibodies
Molecular Weight

872.95

Formula

C45H49FN12O6
CAS No.
SMILES

O=C1C(N2C(C(C=C(N3CCN(CCN4CCN(CCCOC5=CC(N=CN=C6NC7=CC(CC(NC8=CC=CC(F)=C8)=O)=NN7)=C6C=C5)CC4)CC3)C=C9)=C9C2=O)=O)CCC(N1)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC AURKB Degrader-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC AURKB Degrader-13114874-73-3PROTAC AURKB Degrader1PROTAC AURKB Degrader 1PROTACsAurora KinaseSurvivinApoptosisYY1ubiquitin-proteasome systemsurvivinchromosomal passenger complexborealinAURKAAurora kinase BE3 ligase CRBNAURKBINCENPInhibitorinhibitorinhibit

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