3114874-73-3
Chemical Structure
PROTAC AURKB Degrader-1
- CAS No.: 3114874-73-3
- Formula:C45H49FN12O6
- Molecular Weight:872.95
InChIKey: UCJSIGUIZLMHAF-UHFFFAOYSA-N
SMILES: O=C1C(N2C(C(C=C(N3CCN(CCN4CCN(CCCOC5=CC(N=CN=C6NC7=CC(CC(NC8=CC=CC(F)=C8)=O)=NN7)=C6C=C5)CC4)CC3)C=C9)=C9C2=O)=O)CCC(N1)=O
Biological Activity: PROTAC AURKB Degrader-1 is a selective AURKB PROTAC degrader with a DC50 value of 0.6 nM. PROTAC AURKB Degrader-1 promotes ubiquitination and degradation of AURKB. PROTAC AURKB Degrader-1 downregulates the expression levels of chromosomal passenger complex components Borealin, INCENP, Survivin as well as the transcription factor YY1. PROTAC AURKB Degrader-1 induces G2/M phase arrest and triggers Apoptosis in cells. PROTAC AURKB Degrader-1 serves as a chemical probe for biological studies of the chromosomal passenger complex. PROTAC AURKB Degrader-1 can be used in research related to acute myeloid leukemia, colorectal cancer, and non-small cell lung cancer[1].
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PROTAC AURKB Degrader-1 | PROTAC AURKB Degrader-1 is a selective AURKB PROTAC degrader with a DC50 value of 0.6 nM. PROTAC AURKB Degrader-1 promotes ubiquitination and degradation of AURKB. PROTAC AURKB Degrader-1 downregulates the expression levels of chromosomal passenger complex components Borealin, INCENP, Survivin as well as the transcription factor YY1. PROTAC AURKB Degrader-1 induces G2/M phase arrest and triggers Apoptosis in cells. PROTAC AURKB Degrader-1 serves as a chemical probe for biological studies of the chromosomal passenger complex. PROTAC AURKB Degrader-1 can be used in research related to acute myeloid leukemia, colorectal cancer, and non-small cell lung cancer. | |||||||||||||||||||||
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