hAChE-IN-6
hAChE-IN-6 (compound 51) is a brain penetrant AChE inhibitor with an IC50 of 0.16 μM. hAChE-IN-6 also inhibits hBuChE and GSK3β with IC50 values of 0.69 μM and 0.26 μM, respectively. hAChE-IN-6 inhibits tau protein and Aβ1-42 self-aggregation, and can be used for Alzheimer's disease (AD) research.
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- CAS. Nr.: 3007667-17-3
- Formel: C20H17BrN4O2
- Molecular Weight:425.28
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
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Help & FAQs
Biologische Aktivität
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hAChE 0.16 μM (IC50) |
hBCHE 0.69 μM (IC50) |
GSK-3β 0.26 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
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| WI-38 | IC50 |
84.51 μM
Compound: 51
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Cytotoxicity against human WI-38 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human WI-38 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
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[PMID: 37871406] |
Chemical Information
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CAS. Nr. 3007667-17-3
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Molecular Weight 425.28
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Formel C20H17BrN4O2
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SMILES
NC1=NNC2=NC(C3=CC=C(Br)C=C3)=CC(C4=CC(OC)=C(OC)C=C4)=C21
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
hAChE-IN-6 Related Classifications
HY-155366 Related Classifications
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