3007667-17-3
3007667-17-3
Chemical Structure
hAChE-IN-6
- CAS No.: 3007667-17-3
- Formula:C20H17BrN4O2
- Molecular Weight:425.28
InChIKey: CFUZORHXMOWNMN-UHFFFAOYSA-N
SMILES: NC1=NNC2=NC(C3=CC=C(Br)C=C3)=CC(C4=CC(OC)=C(OC)C=C4)=C21
Biological Activity: hAChE-IN-6 (compound 51) is a brain penetrant AChE inhibitor with an IC50 of 0.16 μM. hAChE-IN-6 also inhibits hBuChE and GSK3β with IC50 values of 0.69 μM and 0.26 μM, respectively. hAChE-IN-6 inhibits tau protein and Aβ1-42 self-aggregation, and can be used for Alzheimer's disease (AD) research[1].
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hAChE-IN-6 | hAChE-IN-6 (compound 51) is a brain penetrant AChE inhibitor with an IC50 of 0.16 μM. hAChE-IN-6 also inhibits hBuChE and GSK3β with IC50 values of 0.69 μM and 0.26 μM, respectively. hAChE-IN-6 inhibits tau protein and Aβ1-42 self-aggregation, and can be used for Alzheimer's disease (AD) research. | |||||||||||||||||||||
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References
Keywords
