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Art. -Nr.: HY-112448

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Lck-IN-6

Lck-IN-6 (Compound 12g) is a Lck inhibitor with an IC₅₀ of 3 nM. Lck-IN-6 inhibits the production of IL-2. Lck-IN-6 can be used in the research of rheumatoid arthritis and inflammatory bowel disease.

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CAS. Nr.: 918870-43-6
Formel: C₂₄H₂₆N₆O₃
Molecular Weight:446.51

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Lck-IN-6 Chemical Structure

CAS. Nr.: 918870-43-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

Lck

3 nM (IC₅₀)

Alle Src Isoform-spezifische Produkte anzeigen :

Alle Interleukin Related Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
Jurkat	IC₅₀	0.054 μM Compound: 12g	Inhibition of IL2 production in Jurkat E6-1 T cells by ELISA Inhibition of IL2 production in Jurkat E6-1 T cells by ELISA	[PMID: 16997556]

In Vitro

Lck-IN-6 inhibits recombinant human active Lck with an IC₅₀ of 3 nM^[1].
Lck-IN-6 inhibits IL-2 production in stimulated Jurkat E6-1 human acute T cell leukemia cells with an IC₅₀ of 0.054 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 918870-43-6
Molecular Weight 446.51
Formel C₂₄H₂₆N₆O₃
SMILES

OC1=CC=C(C(=C1)NC2=NC(=NC(OCCN3CCOCC3)=C2)N4C=NC=5C=CC=CC54)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Sabat M, et al. The development of 2-benzimidazole substituted pyrimidine based inhibitors of lymphocyte specific kinase (Lck). Bioorg Med Chem Lett. 2006;16(23):5973-5977. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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Lck-IN-6

Alle Src Isoform-spezifische Produkte anzeigen

Alle Interleukin Related Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Lck-IN-6 Related Classifications

HY-112448 Related Classifications