Multi-kinase-IN-13
Multi-kinase-IN-13 (Compound 10F) is an inhibitor of AChE, BuChE, and GSK-3β, with an IC50 of 3 nM against hAChE, 303 nM against hBuChE, and 7.58 nM against GSK-3β. Multi-kinase-IN-13 exhibits in vitro iron chelating activity. AChE-IN-110 can be used in the research of Alzheimer's disease.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C24H18N2O4
- Molecular Weight:398.41
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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GSK-3β 7.58 nM (IC50) |
hAChE 3 nM (IC50) |
hBCHE 303 nM (IC50) |
Multi-kinase-IN-13 (10 min) potently inhibits hAChE in vitro with an IC50 of 3 nM, which is 2.3 times more potent than Donepezil (HY-14566)[1].
Multi-kinase-IN-13 (0.003-10 μM) inhibits hBuChE in vitro, with an IC50 of 303 nM[1].
Multi-kinase-IN-13 potently inhibits GSK-3β in vitro with an IC50 of 7.58 nM[1].
Multi-kinase-IN-13 (0.003-10 mg/mL) exhibits in vitro iron chelating activity with an IC50 value of 0.162 mg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 398.41
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Formel C24H18N2O4
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SMILES
O=C(NC1=CC=CC=C1)COC2=CC=C(C=C2)/C=N/C3=CC=C4OC(C=CC4=C3)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Multi-kinase-IN-13 Related Classifications
HY-182001 Related Classifications
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