Art. -Nr.: HY-126854

N-Acetyllactosamine

(Synonyms: N-Acetyl-D-lactosamine)

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N-Acetyllactosamine (N-Acetyl-D-lactosamine), a nitrogen-containing disaccharide, is a galectin-3 inhibitor, which is an important component of various oligosaccharides such as glycoproteins and sialyl Lewis X. N-Acetyllactosamine can be used as the starting material for the synthesis of various oligosaccharides. N-Acetyllactosamine has prebiotic effects.

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Reinheit: 99.95%
CAS. Nr.: 32181-59-2
Formel: C₁₄H₂₅NO₁₁
Molecular Weight:383.35

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

N-Acetyllactosamine Chemical Structure

CAS. Nr.: 32181-59-2

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Human Endogenous Metabolite

Galectin-3

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen :

Alle Galectin Isoform-spezifische Produkte anzeigen :

In Vitro

N-Acetyllactosamine (0-10 mM, 2 h 10 min) inhibits the binding of type A progenitor toxin to intestine-407 cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

N-Acetyllactosamine (5 mg/kg, sham operation, every other day at week 4) significantly improves the blood pressure, and systolic and diastolic cardiomyocyte contractility in cirrhotic rats^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Cirrhotic rats^[4]
Dosage:

5 mg/kg
Administration:

sham operation, every other day at week 4
Result:

Significantly decreased galectin-3 expression and BNP levels in left ventricles from BDL rats and restored systolic contractility in cirrhotic cardiomyocytes.

Chemical Information

CAS. Nr. 32181-59-2
Appearance Solid
Molecular Weight 383.35
Formel C₁₄H₂₅NO₁₁
Color White to off-white
SMILES

O=C[C@H](NC(C)=O)[C@H]([C@@H]([C@@H](CO)O)O[C@H]1[C@@H]([C@H]([C@H]([C@@H](CO)O1)O)O)O)O
Synonyms

N-Acetyl-D-lactosamine
Structure Classification
- Others
Initial Source
- Microorganisms
Escherichia coli strains and Corynebacterium ammoniagenes
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Lösungsmittel & Löslichkeit

In Vitro:

H₂O : 100 mg/mL (260.86 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.6086 mL

13.0429 mL

26.0858 mL

5 mM

0.5217 mL

2.6086 mL

5.2172 mL

10 mM

0.2609 mL

1.3043 mL

2.6086 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Endo T, Koizumi S, Tabata K, Kakita S, Ozaki A. Large-scale production of N-acetyllactosamine through bacterial coupling. Carbohydr Res. 1999 Mar 31;316(1-4):179-83. [Content Brief]

[2]. M.Karimi Alavijeh, et al. Simulation and economic assessment of large-scale enzymatic N-acetyllactosamine manufacture. Biochemical Engineering Journal. Volume 154, 15 February 2020, 107459

[3]. Kojima S, et al. Clostridium botulinum type A progenitor toxin binds to Intestine-407 cells via N-acetyllactosamine moiety. Biochem Biophys Res Commun. 2005 Jun 3;331(2):571-6. [Content Brief]

[4]. Yoon KT, et al. Galectin-3 inhibits cardiac contractility via a tumor necrosis factor alpha-dependent mechanism in cirrhotic rats. Clin Mol Hepatol. 2022 Apr;28(2):232-241. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	2.6086 mL	13.0429 mL	26.0858 mL	65.2146 mL
	5 mM	0.5217 mL	2.6086 mL	5.2172 mL	13.0429 mL
	10 mM	0.2609 mL	1.3043 mL	2.6086 mL	6.5215 mL
	15 mM	0.1739 mL	0.8695 mL	1.7391 mL	4.3476 mL
	20 mM	0.1304 mL	0.6521 mL	1.3043 mL	3.2607 mL
	25 mM	0.1043 mL	0.5217 mL	1.0434 mL	2.6086 mL
	30 mM	0.0870 mL	0.4348 mL	0.8695 mL	2.1738 mL
	40 mM	0.0652 mL	0.3261 mL	0.6521 mL	1.6304 mL
	50 mM	0.0522 mL	0.2609 mL	0.5217 mL	1.3043 mL
	60 mM	0.0435 mL	0.2174 mL	0.4348 mL	1.0869 mL
	80 mM	0.0326 mL	0.1630 mL	0.3261 mL	0.8152 mL
	100 mM	0.0261 mL	0.1304 mL	0.2609 mL	0.6521 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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N-Acetyllactosamine

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

Natural Product Library

Human Endogenous Metabolite Compound Library

Covalent Screening Library

Anti-Cardiovascular Disease Compound Library

Microbial Metabolite Library

Food-Sourced Compound Library

Human Metabolite Library

Anti-Pulmonary Fibrosis Compound Library

Heterocyclic Compound Library

Animal-Sourced Natural Product Library

Highly Selective Inhibitors Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Covalent Screening Library Plus

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Protein Kinase Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Mass Spectrometry Human Endogenous Metabolite Library

Mass Spectrometry Human Metabolite Library

Mouse Metabolite Compound Library

Mass Spectrometry Natural Product Library

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen

Alle Galectin Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

N-Acetyllactosamine

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

Natural Product Library

Human Endogenous Metabolite Compound Library

Covalent Screening Library

Anti-Cardiovascular Disease Compound Library

Microbial Metabolite Library

Food-Sourced Compound Library

Human Metabolite Library

Anti-Pulmonary Fibrosis Compound Library

Heterocyclic Compound Library

Animal-Sourced Natural Product Library

Highly Selective Inhibitors Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Covalent Screening Library Plus

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Protein Kinase Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Mass Spectrometry Human Endogenous Metabolite Library

Mass Spectrometry Human Metabolite Library

Mouse Metabolite Compound Library

Mass Spectrometry Natural Product Library

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen

Alle Galectin Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

N-Acetyllactosamine Related Classifications

HY-126854 Related Classifications