PAK1-IN-1
PAK1-IN-1 is a potent and selective PAK1 inhibitor with an IC50 of 9.8 nM. PAK1-IN-1 inhibits the migration and invasion of PAK1-related tumour cells in a dose-dependent manner.
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- CAS. Nr.: 2485732-30-5
- Formel: C26H20ClN5O2
- Molecular Weight:469.92
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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PAK1 9.8 nM (IC50) |
PAK4 >10 μM (IC50) |
PAK1-IN-1 (compound 30l) (0-10 µM) shows selectivity with IC50s of 0.01, >10 µM for PAK1 and PAK4, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231, HCT-116 cells
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Concentration:1 µM
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Incubation Time:72 h
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Result:Showed antiproliferative activity against MDA-MB-231and HCT-116 cells with inhibition of 6.31% and 8.73%, respectively.
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Cell Line:MDA-MB-231 cells
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Concentration:2.5, 5, 10, 20 µM
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Incubation Time:1, 24 h
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Result:Decreased the expression of activated PAK1 (PAKp-Ser144) and Snail in a dose-dependent manner.
Chemical Information
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CAS. Nr. 2485732-30-5
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Molecular Weight 469.92
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Formel C26H20ClN5O2
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SMILES
CC1=CC=CN(C1=O)C2=CC=C(C(Cl)=C2)C3=CC=C4C(NN=C4C(NCC5=CC=NC=C5)=O)=C3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
PAK1-IN-1 Related Classifications
HY-146681 Related Classifications
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