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Art. -Nr.: HY-18794

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R-03201195

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

R-03201195 is an efficient and selective p38 MAP kinase inhibitor with an IC₅₀ for p38α of 0.7 nM. R-03201195 has inhibitory activity against TNF-α in THP-1 cells and against IL-1β in human whole blood, with IC₅₀ values of 0.25 and 0.57 nM respectively. R-03201195 can be used for inflammatory diseases such as rheumatoid arthritis.

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CAS. Nr.: 249936-55-8
Formel: C₁₉H₁₈FN₃O₄
Molecular Weight:371.36

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Data Sheet (272 KB)

R-03201195 Chemical Structure

CAS. Nr.: 249936-55-8

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
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Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

p38 MAP kinase

IL-1β

Alle p38 MAPK Isoform-spezifische Produkte anzeigen :

Alle TNF Receptor Isoform-spezifische Produkte anzeigen :

Alle Interleukin Related Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
THP-1	IC₅₀	0.25 μM Compound: 63	Inhibition of LPS-induced TNFalpha production in THP1 cells Inhibition of LPS-induced TNFalpha production in THP1 cells	[PMID: 16509574]
THP-1	IC₅₀	250 nM Compound: Ro-3201195	Inhibition of p38alpha-induced TNFalpha production in human THP1 cells Inhibition of p38alpha-induced TNFalpha production in human THP1 cells	[PMID: 18539026]

Chemical Information

CAS. Nr. 249936-55-8
Molecular Weight 371.36
Formel C₁₉H₁₈FN₃O₄
SMILES

OC[C@H](O)COC1=CC=CC(C(C2=C(N)N(C3=CC=C(F)C=C3)N=C2)=O)=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Front Med

Wogonoside alleviates hyperosmotic stress-induced inflammation and apoptosis in human corneal epithelial cells via PI3K/AKT signaling. [Abstract]

2026 May 4:13:1828021. PMID: 42210954

Reinheit & Dokumentation

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Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Goldstein DM, et al. Discovery of S-[5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]-[3-(2,3-dihydroxypropoxy)phenyl]methanone (RO3201195), an orally bioavailable and highly selective inhibitor of p38 MAP kinase. J Med Chem. 2006 Mar 9;49(5):1562-75. [Content Brief]

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Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

R-03201195

1 Cited Publications

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Biologische Aktivität
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Publications (1)
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R-03201195

Publications Citing Use of MedChemExpress (MCE) R-03201195

Alle p38 MAPK Isoform-spezifische Produkte anzeigen

Alle TNF Receptor Isoform-spezifische Produkte anzeigen

Alle Interleukin Related Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (1)

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R-03201195 Related Classifications

HY-18794 Related Classifications