249936-55-8
Chemical Structure
R-03201195
- CAS No.: 249936-55-8
- Formula:C19H18FN3O4
- Molecular Weight:371.36
IUPAC Name: (S)-(5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl)(3-(2,3-dihydroxypropoxy)phenyl)methanone
InChIKey: IJDQETGUEUJVTB-HNNXBMFYSA-N
SMILES: OC[C@H](O)COC1=CC=CC(C(C2=C(N)N(C3=CC=C(F)C=C3)N=C2)=O)=C1
Biological Activity: R-03201195 is an efficient and selective p38 MAP kinase inhibitor with an IC50 for p38α of 0.7 nM. R-03201195 has inhibitory activity against TNF-α in THP-1 cells and against IL-1β in human whole blood, with IC50 values of 0.25 and 0.57 nM respectively. R-03201195 can be used for inflammatory diseases such as rheumatoid arthritis[1].
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R-03201195 | R-03201195 is an efficient and selective p38 MAP kinase inhibitor with an IC50 for p38α of 0.7 nM. R-03201195 has inhibitory activity against TNF-α in THP-1 cells and against IL-1β in human whole blood, with IC50 values of 0.25 and 0.57 nM respectively. R-03201195 can be used for inflammatory diseases such as rheumatoid arthritis. | |||||||||||||||||||||
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Keywords
