Aurora A inhibitor 4
Aurora A inhibitor 4 (compound C9) is a potent inhibitor of Aurora A, with the GI50 of 4.26 and 7.08 μM in DU 145 cells and HT-29 cells, respectively.
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- CAS No.: 371224-09-8
- Formule: C22H23N5O3
- Masse moléculaire:405.45
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
|
Aurora A |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| DU-145 | GI50 |
4.26 μM
Compound: BAS 0345 0373
|
Cytotoxicity against human DU145 cells after 4 hrs by MTT assay
Cytotoxicity against human DU145 cells after 4 hrs by MTT assay
|
[PMID: 21194953] |
| HT-29 | GI50 |
7.08 μM
Compound: BAS 0345 0373
|
Cytotoxicity against human HT-29 cells after 4 hrs by MTT assay
Cytotoxicity against human HT-29 cells after 4 hrs by MTT assay
|
[PMID: 21194953] |
Chemical Information
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CAS No. 371224-09-8
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Masse moléculaire 405.45
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Formule C22H23N5O3
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SMILES
O=C1N=C(NC(C1)C2=CC=C(C=C2)OC)NC3=NC(C)=C4C=C(OCC)C=CC4=N3
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Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)