CAIX/XII-IN-18
CAIX/XII-IN-18 is a selective human carbonic anhydrase IX/XII (CA IX/XII) inhibitor with Ki values of 28.1 nM (hCA IX) and 11.6 nM (hCA XII). CAIX/XII-IN-18 induces apoptosis in breast cancer cells. CAIX/XII-IN-18 can be used for the research of breast cancer, pancreatic cancer.
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- Formule: C22H17ClN8O2S2
- Masse moléculaire:525.01
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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hCA IX 28.1 nM (Ki) |
hCA XII 11.6 nM (Ki) |
CAIX/XII-IN-18 (Compound 4g) (15 min) potently inhibits recombinant human hCA IX (Ki = 28.1 nM) and hCA XII (Ki = 11.6 nM) with favorable selectivity over hCA I and hCA II[1].
CAIX/XII-IN-18 (100 μM; 48 h) reduces MDA-MB-231 breast cancer cell viability under normoxic and hypoxic conditions[1].
CAIX/XII-IN-18 (100 μM; 48 h) induces apoptosis in MDA-MB-231 breast cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231 breast cancer cells
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Concentration:100 μM
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Incubation Time:48 h
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Result:Significantly reduced MDA-MB-231 cell viability under both normoxic and hypoxic conditions when administered alone.
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Cell Line:MDA-MB-231 breast cancer cells
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Concentration:100 μM
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Incubation Time:48 h
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Result:Induced a clear redistribution of the MDA-MB-231 cell population, with a significant reduction in the viable cell fraction and a corresponding increase in apoptotic cells compared to untreated controls.
Chemical Information
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Masse moléculaire 525.01
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Formule C22H17ClN8O2S2
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SMILES
O=S(C1=CC=C(N2N=NC(CSC3=NN=C(C4=CC=NC=C4)N3C5=CC=CC=C5Cl)=C2)C=C1)(N)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CAIX/XII-IN-18 Related Classifications
HY-183591 Related Classifications
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