DHODH-IN-25
DHODH-IN-25 (Compound 25) is an orally active dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 value of 5.4 nM for human DHODH. DHODH-IN-25 can be used for the study of acute myeloid leukemia (AML).
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- CAS No.: 2619531-95-0
- Formule: C22H19ClF5N3O5
- Masse moléculaire:535.85
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
IC50: 5.4 nM (hDHODH)[1].
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MOLM-13 | IC50 |
0.92 nM
Compound: 25
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Antiproliferative activity in human MOLM-13 AML cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Glo assay
Antiproliferative activity in human MOLM-13 AML cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Glo assay
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[PMID: 38505861] |
Chemical Information
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CAS No. 2619531-95-0
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Masse moléculaire 535.85
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Formule C22H19ClF5N3O5
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SMILES
O=C(N1C(CO)CCC1=O)NC2=CC(O[C@@H](C)C(F)(F)F)=C(C(NC3=C(F)C=CC=C3Cl)=O)C=C2F
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DHODH-IN-25 Related Classifications
HY-163328 Related Classifications
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