PIK-75 (Standard)
PIK-75 (Standard) is the analytical standard of PIK-75 (HY-107834). This product is intended for research and analytical applications. PIK-75 is a reversible DNA-PK and p110α-selective inhibitor, which inhibits DNA-PK, p110α and p110γ with IC50s of 2, 5.8 and 76 nM, respectively. PIK-75 inhibits p110α >200-fold more potently than p110β (IC50=1.3 μM). PIK-75 induces apoptosis.
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- CAS No.: 372196-67-3
- Formule: C16H14BrN5O4S
- Masse moléculaire:452.28
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
IC50: 2 nM (DNA-PK), 5.8 nM (p110α), 76 nM (p110γ), 510 nM (p110δ), ~1 μM (PI3KC2β), ~1 μM (mTORC1), 1.3 μM (p110β), 2.3 μM (ATM), 2.6 μM (hsVPS34), ~10 μM (PI3KC2α), ~10 μM (mTORC2), ~50 μM (PI4KIIIβ), 21 μM (ATR)[1]
Chemical Information
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CAS No. 372196-67-3
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Masse moléculaire 452.28
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Formule C16H14BrN5O4S
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SMILES
O=S(C1=CC([N+]([O-])=O)=CC=C1C)(N(C)/N=C/C2=CN=C3C=CC(Br)=CN32)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Knight ZA, et al. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell. 2006 May 19;125(4):733-47. [Content Brief]
[2]. Chaussade C, et al. Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling. Biochem J. 2007 Jun 15;404(3):449-58. [Content Brief]
[3]. Duong HQ, et al. Inhibition of NRF2 by PIK-75 augments sensitivity of pancreatic cancer cells to gemcitabine. Int J Oncol. 2014 Mar;44(3):959-69. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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