STAT3-IN-17
Based on 1 Customer Validation
STAT3-IN-17 is a moderate STAT3 inhibitor (IC50=0.7 μM; HEK-Blue IL-6), with antiproliferative activity in HeLa cells. STAT3-IN-17 has good pharmacokinetic characteristics. STAT3-IN-17 also inhibits pyruvate-ferredoxin oxidoreductase (PFOR), and inhibits Helicobacter pylori.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 98.0%
- CAS No.: 1245814-52-1
- Formule: C11H6F3N3O3S
- Masse moléculaire:317.24
-
Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
-
Solvant et solubilité
- Pureté et documentation
- Références
-
Help & FAQs
-
Differentiation Inducing Compound Library
HY-L038
-
Anti-Breast Cancer Compound Library
HY-L074
-
Anti-Lung Cancer Compound Library
HY-L075
-
Anti-Pancreatic Cancer Compound Library
HY-L077
-
Anti-Blood Cancer Compound Library
HY-L079
-
Anti-Obesity Compound Library
HY-L087
-
Transcription Factor-Targeted Library
HY-L090
-
Anti-Liver Cancer Compound Library
HY-L101
-
Antidepressant Compound Library
HY-L108
-
Anti-Prostate Cancer Compound Library
HY-L124
-
Cancer Stem Cells Compound Library
HY-L135
-
Pain-Related Compound Library
HY-L139
-
Anti-Hematopathy Compound Library
HY-L171
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Bioactive Compound Library
HY-L001
-
Cell Proliferation Compound Library
HY-L201
-
High-Throughput Bioactive Compound Library
HY-L205
-
Posttranslational Modification Library
HY-L226
-
Lactylation Compound Library
HY-L249
-
Anti-Infection Compound Library
HY-L002
-
Immunology/Inflammation Compound Library
HY-L007
-
JAK/STAT Compound Library
HY-L008
-
Kinase Inhibitor Library
HY-L009
-
Stem Cell Signaling Compound Library
HY-L017
-
Anti-Cancer Compound Library
HY-L025
-
Small Molecule Immuno-Oncology Compound Library
HY-L031
-
Anti-Aging Compound Library
HY-L034
Activité biologique
|
STAT3 |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
3 μM
Compound: 15
|
Antiproliferative activity against human A549 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
|
[PMID: 34055214] |
| Caco-2 | IC50 |
1.8 μM
Compound: 15
|
Antiproliferative activity against human Caco-2 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
Antiproliferative activity against human Caco-2 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
|
[PMID: 34055214] |
| HeLa | IC50 |
1.8 μM
Compound: 15
|
Antiproliferative activity against human HeLa cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
|
[PMID: 34055214] |
| HeLa | IC50 |
2.7 μM
Compound: 15
|
Cytotoxicity against human HeLa cells assessed as inhibition of cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as inhibition of cell viability measured after 48 hrs by MTT assay
|
[PMID: 34055214] |
| HL-60 | IC50 |
1.2 μM
Compound: 15
|
Antiproliferative activity against human HL60 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
Antiproliferative activity against human HL60 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
|
[PMID: 34055214] |
| HT-29 | IC50 |
>10 μM
Compound: 15
|
Antiproliferative activity against human HT29 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
Antiproliferative activity against human HT29 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
|
[PMID: 34055214] |
| PC-3 | IC50 |
>10 μM
Compound: 15
|
Antiproliferative activity against human PC3 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
Antiproliferative activity against human PC3 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
|
[PMID: 34055214] |
STAT3-IN-17 (compound 15) (10 μM; 20 h, 48 h) inhibits STAT3 pathway with inhibition rate of 76.5%, and also inhibits HEK-Blue IL-6 cells viability to 15%[1].
STAT3-IN-17 (2.5-40 μM; 24 h) inhibits the phosphorylation of STAT3 (Y705)[1].
STAT3-IN-17 (10 μM, 50 μM; 48 h) inhibits HEK 293T cell growth, as well as inhibiting HeLa cell growth with an IC50 value of 2.7 μM[1].
(D)-PPA 1 (compound 24) inhibits microorganisms Helicobacter pylori and Campylobacter jejuni with MIC values of 1.6 μM and 4.7 μM, respectively[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 1245814-52-1
-
Appearance Solid
-
Masse moléculaire 317.24
-
Formule C11H6F3N3O3S
-
Color Light yellow to yellow
-
SMILES
O=C(NC1=NC=C([N+]([O-])=O)S1)C2=CC=C(C(F)(F)F)C=C2
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 25 mg/mL (78.80 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
-
Fiche technique (273 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1522 mL | 15.7609 mL | 31.5219 mL | 78.8047 mL |
| 5 mM | 0.6304 mL | 3.1522 mL | 6.3044 mL | 15.7609 mL | |
| 10 mM | 0.3152 mL | 1.5761 mL | 3.1522 mL | 7.8805 mL | |
| 15 mM | 0.2101 mL | 1.0507 mL | 2.1015 mL | 5.2536 mL | |
| 20 mM | 0.1576 mL | 0.7880 mL | 1.5761 mL | 3.9402 mL | |
| 25 mM | 0.1261 mL | 0.6304 mL | 1.2609 mL | 3.1522 mL | |
| 30 mM | 0.1051 mL | 0.5254 mL | 1.0507 mL | 2.6268 mL | |
| 40 mM | 0.0788 mL | 0.3940 mL | 0.7880 mL | 1.9701 mL | |
| 50 mM | 0.0630 mL | 0.3152 mL | 0.6304 mL | 1.5761 mL | |
| 60 mM | 0.0525 mL | 0.2627 mL | 0.5254 mL | 1.3134 mL |
STAT3-IN-17 Related Classifications
HY-148706 Related Classifications
Powered by Bioz